IN VITRO STUDIES ON THE ANTI-INFLAMMATORY EFFECTS OF ESSENTIAL OIL OF Rosmarinus officinalis L. IN MACROPHAGE CELLS

被引：0
作者：
Kavitha, K. R. [1 ]
Suma, B. S. [1 ]
Jyothilekshmi, B. [1 ]
Prasanth, K. P. [2 ]
机构：
[1] Sree Narayana Coll, Dept Bot, Thiruvananthapuram 695587, Kerala, India
[2] Sree Narayana Coll, Dept Bot, Kannur 670007, Kerala, India
来源：
APPLIED BIOLOGICAL RESEARCH | 2024年 / 26卷 / 01期
关键词：
Anti-inflammation; essential oil; macrophage cells; protein denaturation; Rosmarinus officinalis; OCIMUM-BASILICUM L; CONSTITUENTS;
D O I：
10.48165/abr.2024.26.01.14
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The use of plant-based drugs against various human disorders have attained global interest. Multicomponent essential oils are used to cure inflammationrelated disorders. The present study was aimed to assess the antiinflammatory potential of essential oil from Rosmarinus officinalis (EORO) using in vitro model of LPS-activated RAW macrophage cell lines. EO-RO was hydro-distilled using Clevenger apparatus and evaluated first for protein denaturation and proteinase inhibitory activities, followed by assays for cyclooxygenase (COX) and lipoxygenase (LOX) activities in RAW 264.7 macrophage cell lines. The data was statistically analysed by one-way analysis of variance. Dose-dependent inhibition was observed in protein denaturation with 50 mu g mL(-1) EO-RO exhibiting a maximum inhibition of The COX and LOX activities showed increased inhibitions in dose-dependent manner i.e. 25 to 100 mu g mL(-1) EO-RO displayed 58.72 and 75.33%; 28.5840.86% inhibition, respectively.
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页码：136 / 141
页数：6
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