The impact of sex in the effectiveness of functional remediation in bipolar disorder

被引:1
作者
Serra-Navarro, Maria [1 ,2 ,3 ,4 ]
Clougher, Derek [1 ,2 ,3 ,4 ,5 ]
Sole, Brisa [1 ,2 ,3 ,4 ]
Sanchez-Moreno, Jose [1 ,2 ,3 ,4 ]
Gonzalez-Pinto, Ana [4 ,5 ]
Jimenez, Esther [1 ,4 ,5 ]
Amann, Benedikt L. [4 ,6 ,7 ]
Balanza-Martinez, Vicent [4 ,8 ]
Tabares-Seisdedos, Rafael [4 ,8 ]
Arango, Celso [4 ,9 ]
Accardo, Vivian [10 ]
Garcia-Portilla, Maria Paz [4 ,11 ]
Ibanez, Angela [4 ,12 ]
Crespo, Jose Manuel [4 ,13 ]
Ayuso-Mateos, Jose Luis [4 ,14 ]
Amoretti, Silvia [15 ]
Torrent, Carla [1 ,2 ,3 ,4 ]
Martinez-Aran, Anabel [1 ,2 ,3 ,4 ]
Vieta, Eduard [1 ,2 ,3 ,4 ]
机构
[1] Hosp Clin Barcelona, Dept Psychiat & Psychol, Bipolar & Depress Disorders Unit, Barcelona, Spain
[2] Inst Invest Biomed August Pi i Sunyer FCRB IDIBAPS, Fundacio Clin Recerca Biomed, Barcelona, Spain
[3] Univ Barcelona, Inst Neurosci UBNeuro, Fac Med & Ciencies Salut, Dept Med, Barcelona, Spain
[4] Hlth Inst Carlos III ISCIII, Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
[5] Univ Basque Country, Alava Univ Hosp, BIOARABA, Vitoria, Spain
[6] Hosp Mar Med Res Inst, Inst Mental Hlth, Barcelona, Spain
[7] Pompeu Fabra Univ, Dept Med & Life Sci, Barcelona, Spain
[8] Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, INCLIVA, Valencia, Spain
[9] Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Sch Med, IiSGM,Child & Adolescent Psychiat Dept, Madrid, Spain
[10] ASST Spedali Civili Brescia, Dept Mental Hlth, Addict Serv, Brescia, Italy
[11] Univ Oviedo, Inst Neurociencias Principado Asturias, Sch Med, INEUROPA,Dept Psychiat,Serv Salud Principado Astur, Oviedo, Spain
[12] Univ Alcala, Hosp Univ Ramon & Cajal, Inst Ramon & Cajal Invest Sanitaria IRYCIS, Dept Psychiat, Madrid, Spain
[13] Univ Hosp Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Barcelona, Spain
[14] Univ Autonoma Madrid, Dept Psychiat, IIS IP, Madrid, Spain
[15] Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain
基金
美国国家卫生研究院;
关键词
bipolar disorder; functional remediation; psychosocial functioning; sex differences; GENDER-DIFFERENCES; RATING-SCALE; SCHIZOPHRENIA; PERFORMANCE; DEPRESSION; MEMORY; MANIA;
D O I
10.1111/acps.13748
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
BackgroundFunctional recovery remains a core clinical objective for patients with bipolar disorder (BD). Sociodemographic, clinical, and neurocognitive variables are associated with long-term functional impairment, yet the impact of sex differences is unclear. Functional remediation (FR) is a validated intervention aimed at achieving functional recovery in BD. The present study assessed the effect of sex differences of FR on psychosocial functioning at post-treatment (6-months) and 12-month follow-up (FUP). To the best of our knowledge, this is the first study to explore the role of sex as a factor in the efficacy of FR.Methods157 participants with BD were randomly assigned to either FR (N = 77) or treatment as usual group (80). Clinical, sociodemographic, neuropsychological, and functional data were obtained using a comprehensive assessment battery. Sex differences were explored via a general linear model (GLM) for repeated measures to compare the effect of sex on the intervention over time (6 months and FUP).ResultsResults demonstrated that FR benefits both sexes, males (p = 0.001; d' = 0.88) and females (p = 0.04; d' = 0.57), at 6 months suggesting a generalized functional improvement. Conversely, at 12-month FUP sex differences were observed only in males (p = 0.005; d' = 0.68).ConclusionsFR is a beneficial intervention for males and females after treatment, suggesting that there are no relevant distinct needs. Females may benefit from ongoing psychosocial functioning booster sessions after the intervention to maintain original improvements. Future research exploring sex differences could help to identify strategies to offer personalized FR intervention approaches in individuals with BD.
引用
收藏
页码:543 / 561
页数:19
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