IN SILICO AND IN VITRO EVALUATION OF SILK FIBROIN BASED AMORPHOUS BALL-MILLED BINARY SOLID DISPERSION FOR IMPROVED SOLUBILITY, DISSOLUTION AND TABLETTABILITY: THE CASE OF NAPROXEN

被引：0
作者：
Pantwalawalkar, Jidnyasa [1 ]
Nangare, Sopan [2 ]
Ghagare, Pravin [1 ]
Jadhav, Kisan [3 ]
Jadhav, Namdeo [1 ]
机构：
[1] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut, Kolhapur 416013, Maharashtra, India
[2] H R Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, India
[3] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut, Navi Mumbai 400614, Maharashtra, India
来源：
CELLULOSE CHEMISTRY AND TECHNOLOGY | 2024年 / 58卷 / 3-4期
关键词：
ball milling; dissolution; naproxen; silk fibroin; solid dispersion; solubility; tablet stability; RELEASE; INDOMETHACIN; MICROSPHERES; FORMULATION; BIOAVAILABILITY; ENHANCEMENT; STABILITY; MECHANISM;
D O I：
10.35812/CelluloseChemTechnol.2024.58.25
中图分类号：
TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];
学科分类号：
0805 ; 080502 ; 0822 ;
摘要：
The present study aims to use a natural protein silk fibroin (SF) to enhance solubility, dissolution, tablettability, and subsequently, delivery of naproxen (NP) using a green technique - ball milling. The development of SF and NP solid dispersion (SF-NP-SD) for enhancing the solubility, dissolution, and compatibility of NP using ball milling. In silico molecular docking indicated a strong binding affinity of SF towards NP. Herein, SF-NP-SD (1:1) showed significant improvement (p < 0.05) in saturation solubility (12 fold) and dissolution (1.46 fold) of NP. Along with reduced wetting time (p < 0.05), optimum values of flowability, compressibility, and compatibility were noteworthy. The spectroscopic analysis confirmed favorable interactions, amorphization, and stabilization of NP. The tablet formulation of SF-NP-SD exhibited 1.38-fold enhanced dissolution. Molecular-level hydrophobic and hydrophilic interactions of SF favor molecular-level dispersion, enhance solubility and dissolution, and consecutively, improve drug delivery of NP.
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页码：259 / 270
页数：12
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