AID targeting is dependent on RNA polymerase II pausing

被引：34

作者：

Kenter, Amy L. ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA

来源：

SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

AID targeting; Germline transcription; Epigenetic modifications; RNA polymerase II pausing; INDUCED CYTIDINE DEAMINASE; CLASS SWITCH RECOMBINATION; TRACT-BINDING-PROTEIN; SOMATIC HYPERMUTATION; TRANSCRIPTION ELONGATION; B-CELLS; HISTONE ACETYLATION; R-LOOPS; IMMUNOGLOBULIN GENES; VARIABLE REGION;

D O I：

10.1016/j.smim.2012.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation induced deaminase (AID) is globally targeted to immunoglobulin loci, preferentially focused to switch (S) regions and variable (V) regions, and prone to attack hotspot motifs. Nevertheless, AID deamination is not exclusive to Ig loci and the rules regulating AID targeting remain unclear. Transcription is critically required for class switch recombination and somatic hypermutation. Here, I consider the unique features associated with S region transcription leading to RNA polymerase II pausing, that in turn promote the introduction of activating chromatin remodeling, histone modifications and recruitment of AID to targeted S regions. These findings allow for a better understanding of the interplay between transcription, AID targeting and mistargeting to Ig and non-Ig loci. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：281 / 286

页数：6

共 115 条

[71] Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus
Perlot, Thomas
Alt, Frederick W.
[J]. ADVANCES IN IMMUNOLOGY, VOL 99, 2008, 99 : 1 - 32
[72] Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
Peters, A
Storb, U
[J]. IMMUNITY, 1996, 4 (01) : 57 - 65
[73] Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination
Pinaud, E
Khamlichi, AA
Le Morvan, C
Drouet, M
Nalesso, V
Le Bert, M
Cogné, M
[J]. IMMUNITY, 2001, 15 (02) : 187 - 199
[74] Genome-wide map of nucleosorne acetylation and methylation in yeast
Pokholok, DK
Harbison, CT
Levine, S
Cole, M
Hannett, NM
Lee, TI
Bell, GW
Walker, K
Rolfe, PA
Herbolsheimer, E
Zeitlinger, J
Lewitter, F
Gifford, DK
Young, RA
[J]. CELL, 2005, 122 (04) : 517 - 527
[75] The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription
Rada, C
Yélamos, J
Dean, W
Milstein, C
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) : 3115 - 3120
[76] c-Myc Regulates Transcriptional Pause Release
Rahl, Peter B.
Lin, Charles Y.
Seila, Amy C.
Flynn, Ryan A.
McCuine, Scott
Burge, Christopher B.
Sharp, Phillip A.
Young, Richard A.
[J]. CELL, 2010, 141 (03) : 432 - 445
[77] Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation
Rajagopal, Deepa
Maul, Robert W.
Ghosh, Amalendu
Chakraborty, Tirtha
Khamlichi, Ahmed Amine
Sen, Ranjan
Gearhart, Patricia J.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (06) : 1237 - 1244
[78] Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
Ramiro, AR
Stavropoulos, P
Jankovic, M
Nussenzweig, MC
[J]. NATURE IMMUNOLOGY, 2003, 4 (05) : 452 - 456
[79] Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
Revy, P
Muto, T
Levy, Y
Geissmann, F
Plebani, A
Sanal, O
Catalan, N
Forveille, M
Dufourcq-Lagelouse, R
Gennery, A
Tezcan, I
Ersoy, F
Kayserili, H
Ugazio, AG
Brousse, N
Muramatsu, M
Notarangelo, LD
Kinoshita, K
Honjo, T
Fischer, A
Durandy, A
[J]. CELL, 2000, 102 (05) : 565 - 575
[80] Rosenberg Brad R, 2007, Adv Immunol, V94, P215, DOI 10.1016/S0065-2776(06)94007-3

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