AID targeting is dependent on RNA polymerase II pausing

被引：34

作者：

Kenter, Amy L. ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA

来源：

SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

AID targeting; Germline transcription; Epigenetic modifications; RNA polymerase II pausing; INDUCED CYTIDINE DEAMINASE; CLASS SWITCH RECOMBINATION; TRACT-BINDING-PROTEIN; SOMATIC HYPERMUTATION; TRANSCRIPTION ELONGATION; B-CELLS; HISTONE ACETYLATION; R-LOOPS; IMMUNOGLOBULIN GENES; VARIABLE REGION;

D O I：

10.1016/j.smim.2012.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation induced deaminase (AID) is globally targeted to immunoglobulin loci, preferentially focused to switch (S) regions and variable (V) regions, and prone to attack hotspot motifs. Nevertheless, AID deamination is not exclusive to Ig loci and the rules regulating AID targeting remain unclear. Transcription is critically required for class switch recombination and somatic hypermutation. Here, I consider the unique features associated with S region transcription leading to RNA polymerase II pausing, that in turn promote the introduction of activating chromatin remodeling, histone modifications and recruitment of AID to targeted S regions. These findings allow for a better understanding of the interplay between transcription, AID targeting and mistargeting to Ig and non-Ig loci. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：281 / 286

页数：6

共 115 条

[1] The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila
Andrulis, ED
Werner, J
Nazarian, A
Erdjument-Bromage, H
Tempst, P
Lis, JT
[J]. NATURE, 2002, 420 (6917) : 837 - 841
[2] Increased transcription levels induce higher mutation rates in a hypermutating cell line
Bachl, J
Carlson, C
Gray-Schopfer, V
Dessing, M
Olsson, C
[J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (08) : 5051 - 5057
[3] High-resolution profiling of histone methylations in the human genome
Barski, Artern
Cuddapah, Suresh
Cui, Kairong
Roh, Tae-Young
Schones, Dustin E.
Wang, Zhibin
Wei, Gang
Chepelev, Iouri
Zhao, Keji
[J]. CELL, 2007, 129 (04) : 823 - 837
[4] The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
Basu, Uttiya
Meng, Fei-Long
Keim, Celia
Grinstein, Veronika
Pefanis, Evangelos
Eccleston, Jennifer
Zhang, Tingting
Myers, Darienne
Wasserman, Caitlyn R.
Wesemann, Duane R.
Januszyk, Kurt
Gregory, Richard I.
Deng, Haiteng
Lima, Christopher D.
Alt, Frederick W.
[J]. CELL, 2011, 144 (03) : 353 - 363
[5] Transcription through chromatin: understanding a complex FACT
Belotserkovskaya, R
Saunders, A
Lis, JT
Reinberg, D
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1677 (1-3): : 87 - 99
[6] The complex language of chromatin regulation during transcription
Berger, Shelley L.
[J]. NATURE, 2007, 447 (7143) : 407 - 412
[7] Genomic maps and comparative analysis of histone modifications in human and mouse
Bernstein, BE
Kamal, M
Lindblad-Toh, K
Bekiranov, S
Bailey, DK
Huebert, DJ
McMahon, S
Karlsson, EK
Kulbokas, EJ
Gingeras, TR
Schreiber, SL
Lander, ES
[J]. CELL, 2005, 120 (02) : 169 - 181
[8] Transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination
Besmer, Eva
Market, Eleonora
Papavasiliou, F. Nina
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (11) : 4378 - 4385
[9] A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation
Blagodatski, Artem
Batrak, Vera
Schmidl, Sabine
Schoetz, Ulrike
Caldwell, Randolph B.
Arakawa, Hiroshi
Buerstedde, Jean-Marie
[J]. PLOS GENETICS, 2009, 5 (01):
[10] Modifications of RNA polymerase II are pivotal in regulating gene expression states
Brookes, Emily
Pombo, Ana
[J]. EMBO REPORTS, 2009, 10 (11) : 1213 - 1219

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