Histone deacetylases: potential therapeutic targets for idiopathic pulmonary fibrosis

被引:2
|
作者
Cheng, Hai-peng [1 ,2 ]
Jiang, Shi-he [1 ,2 ]
Cai, Jin [1 ,2 ]
Luo, Zi-qiang [3 ,4 ]
Li, Xiao-hong [1 ,2 ]
Feng, Dan-dan [3 ]
机构
[1] Cent South Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China
[2] Hunan Clin Med Res Ctr Canc Pathogen Genes Testing, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Sch Med, Dept Physiol, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Hunan Key Lab Organ Fibrosis, Changsha, Hunan, Peoples R China
关键词
histone deacetylase; idiopathic pulmonary fibrosis; histone acetylation; fibroblasts; HDAC inhibitors; EPITHELIAL-MESENCHYMAL TRANSITION; DNA METHYLATION; VALPROIC ACID; GENE-EXPRESSION; KAPPA-B; INHIBITOR; CELLS; DIFFERENTIATION; ACETYLATION; CLONING;
D O I
10.3389/fcell.2024.1426508
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown origin and the most common interstitial lung disease. However, therapeutic options for IPF are limited, and novel therapies are urgently needed. Histone deacetylases (HDACs) are enzymes that participate in balancing histone acetylation activity for chromatin remodeling and gene transcription regulation. Increasing evidence suggests that the HDAC family is linked to the development and progression of chronic fibrotic diseases, including IPF. This review aims to summarize available information on HDACs and related inhibitors and their potential applications in treating IPF. In the future, HDACs may serve as novel targets, which can aid in understanding the etiology of PF, and selective inhibition of single HDACs or disruption of HDAC genes may serve as a strategy for treating PF.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option
    Korfei, Martina
    Mahavadi, Poornima
    Guenther, Andreas
    CELLS, 2022, 11 (10)
  • [2] Therapeutic targets in idiopathic pulmonary fibrosis
    Kolb, Martin
    Bonella, Francesco
    Wollin, Lutz
    RESPIRATORY MEDICINE, 2017, 131 : 49 - 57
  • [3] Histone deacetylases function as novel potential therapeutic targets for cancer
    Zhang, Hui
    Shang, Yu-Ping
    Chen, Hong-ying
    Li, Jun
    HEPATOLOGY RESEARCH, 2017, 47 (02) : 149 - 159
  • [4] Aberrant expression and activity of histone deacetylases in idiopathic pulmonary fibrosis (IPF)
    Korfei, Martina
    Klymenko, Oleksiy
    Henneke, Ingrid
    Brand, Peter
    Klepetko, Walter
    Fink, Ludger
    Seeger, Werner
    Kraemer, Oliver
    Guenther, Andreas
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [5] Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis
    Korfei, Martina
    Skwarna, Sylwia
    Henneke, Ingrid
    MacKenzie, BreAnne
    Klymenko, Oleksiy
    Saito, Shigeki
    Ruppert, Clemens
    von der Beck, Daniel
    Mahavadi, Poornima
    Klepetko, Walter
    Bellusci, Saverio
    Crestani, Bruno
    Pullamsetti, Soni Savai
    Fink, Ludger
    Seeger, Werner
    Kraemer, Oliver Holger
    Guenther, Andreas
    THORAX, 2015, 70 (11) : 1022 - 1032
  • [6] Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy
    Kumar, Sonali
    Attrish, Diksha
    Srivastava, Arpna
    Banerjee, Jyotirmoy
    Tripathi, Manjari
    Chandra, P. Sarat
    Dixit, Aparna Banerjee
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2021, 25 (01) : 75 - 85
  • [7] Therapeutic potential of histone deacetylases
    Caron, C
    Khochbin, S
    BIOFUTUR, 2004, (244) : 20 - 22
  • [8] Integrative -Omics Identify Potential Biomarkers and Therapeutic Targets for Idiopathic Pulmonary Fibrosis
    Yang, C.
    Milne, S.
    Allen, R.
    Cordero, A. I. Hernandez
    Li, X.
    Ayoub, A.
    Ask, K.
    Hirota, J. A.
    Bosse, Y.
    Timens, W.
    Hao, K.
    Sin, D. D.
    Jenkins, G.
    Wain, L. V.
    Obeidat, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [9] Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
    Saha, Pritha
    Talwar, Priti
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, 479 (09) : 2181 - 2194
  • [10] Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis
    Sehgal, Manas
    Jakhete, Sharayu Manish
    Manekar, Amruta Ganesh
    Sasikumar, Satish
    HELIYON, 2022, 8 (08)