Diffuse Large B-Cell Lymphoma in a Cynomolgus Monkey

被引：0
作者：
Li, Heling [1 ,2 ]
Zhang, Long [3 ]
Chen, Zhigang [1 ,2 ]
Zong, Faliang [2 ]
Tian, Baohong [1 ]
Chen, Xinglong [1 ]
Liu, Deli [2 ]
Ning, Qing [1 ]
Wang, Hong [1 ,2 ]
机构：
[1] Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Peoples R China
[2] Yunnan Key Lab Primate Biomed Res, Kunming, Peoples R China
[3] Kunming Biomed Int Ltd, Kunming, Peoples R China
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 2024年 / 53卷 / 05期
基金：
中国国家自然科学基金;
关键词：
cynomolgus monkey; diffuse large B-cell lymphoma; mandible; paranasal sinus; NON-HODGKINS-LYMPHOMA; MALIGNANT-LYMPHOMA; MACAQUES;
D O I：
10.1111/jmp.12734
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A captive 17-year-old male cynomolgus monkey (Macaca fascicularis) developed diffuse large B-cell lymphoma (DLBCL). This was the first report of DLBCL presenting with a mandible mass and violation of the paranasal sinus in a cynomolgus monkey. The neoplasm showed marked microscopical malignant aspects. Immunohistochemical staining showed strong positive expression of CD20. These features may contribute to the diagnosis and therapeutics of DLBCL in NHPs.
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