Immunopotentiating effect of lentinan on chicks and its inhibitory effect on Marek's disease virus infection

被引:3
作者
Gao, Qiming [1 ,2 ,3 ]
Li, Shun [1 ,2 ,3 ]
Sun, Wanli [1 ,2 ,3 ]
Yan, Hongjian [1 ,2 ,3 ]
Wang, Yixin [1 ,2 ,3 ]
Chang, Shuang [1 ,2 ,3 ]
Zhao, Peng [1 ,2 ,3 ]
机构
[1] Shandong Agr Univ, Coll Vet Med, Tai An 271018, Shandong, Peoples R China
[2] Shandong Prov Key Lab Anim Biotechnol & Dis Contro, Tai An 271018, Peoples R China
[3] Shandong Prov Engn Technol Res Ctr Anim Dis Contro, Tai An 271018, Peoples R China
关键词
Marek's disease virus; immunosuppression; lentinan; nonspecific immunity; IMMUNE-RESPONSES; IN-VITRO; INTERFERON; POLYSACCHARIDES; PROLIFERATION; EXPRESSION; MUSHROOMS; VIVO;
D O I
10.1016/j.psj.2024.103840
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Marek's disease virus (MDV) is a significant tumorigenic virus that causes severe immunosuppression in chickens. Lentinan (LNT) is an immunomodulator containing /3-glucans and is widely used in areas such as antiviral, anticancer, and immune regulation. To investigate the immunomodulatory effects of LNT on specific pathogen-free (SPF) chicks and its potential to inhibit MDV infection, we conducted an MDV challenge experiment and observed the immune-enhancing effect of LNT on SPF chicks. The results showed that LNT promoted the growth and development of SPF chicks and induced the up- regulation of cytokines such as Mx protein, interferon-g (INF-g), tumor necrosis factor-a (TNF-a), and interleukin-2 (IL-2). The specific gravity of CD4+ + T-lymphocytes and CD8+ + T-lymphocytes and their ratios were also significantly upregulated. Prophylactic use of LNT inhibited MDV replication in lymphocytes, liver, and spleen. It also alleviated MDV-induced weight loss and hepatosplenomegaly in SPF chicks. The present study confirms that LNT can enhance the levels of innate and cellular immunity in SPF chicks and contributes to the inhibition of MDV replication in vivo and mitigation of immune organ damage in chicks due to MDV infection. This provides an adjunctive measure for better control of MDV infection.
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页数:8
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