Prognostic Factors and Outcomes in World Health Organization Grade 1 and Grade 2 Intracranial Meningiomas-5-Year Institutional Experience

被引:0
作者
Nadeem, Mohammed [1 ]
Goyal-Honavar, Abhijit [1 ]
Sravya, Palavalasa [2 ]
Beniwal, Manish [1 ]
Santosh, Vani [3 ]
Dwarakanath, Srinivas [1 ]
机构
[1] Natl Inst Mental Hlth & Neurosci, Dept Neurosurg, Bengaluru, India
[2] Natl Inst Mental Hlth & Neurosci, Neurooncol Lab, Bengaluru, India
[3] Natl Inst Mental Hlth & Neurosci, Dept Neuropathol, Bengaluru, India
关键词
Meningioma; Outcomes; Radiation; Simpson grade; WHO grade; CENTRAL-NERVOUS-SYSTEM; CHROMOSOMAL-ABERRATIONS; RECURRENCE; CLASSIFICATION; RADIOTHERAPY; SURGERY; TUMORS; SURVIVAL;
D O I
10.1016/j.wneu.2024.04.082
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND: Meningiomas are the most frequent primary intracranial tumor. While histological grade and grade of excision are established predictors of recurrence, the predictive ability of other clinical features, such as the role of radical excision of dural attachment and postoperative radiation therapy in intermediate-risk groups, remains unknown.- METHODS: Clinical and radiological features and surgical details were analyzed in 451 World Health Organization (WHO) grade 1 intracranial meningiomas and 248 WHO grade 2 meningiomas operated on between 2010 and 2015. Outcomes were assessed in 352 WHO grade 1 and 208 WHO grade 2 meningiomas, studying the effect of extent of resection and use of radiation therapy. Kaplan-Meier analysis was used to determine differences in survival by extent of resection and use of postoperative radiation therapy in the treatment of the meningiomas.- RESULTS: The mean age of the cohort was 46.3 years, with a female predominance. On univariate analysis, sex, WHO grade, and Simpson grade were significant predictors of recurrence. On multivariate analysis, WHO grade and Simpson grade remained significant predictors of recurrence. Recurrence was significantly associated with poor performance status and mortality. Postoperative radiation significantly improved progression-free survival among patients with grade 2 meningiomas who underwent gross total resection, but not among patients with grade 1 and grade 2 meningiomas who underwent subtotal resection.- CONCLUSIONS: WHO grade and Simpson grade are independent predictors of recurrence in meningiomas. Regardless of WHO grade, gross total resection must be performed when possible, and postoperative radiation therapy may be recommended in grade 2 meningiomas.
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收藏
页码:E331 / E339
页数:9
相关论文
共 32 条
  • [1] RADIATION-THERAPY IN THE TREATMENT OF PARTIALLY RESECTED MENINGIOMAS
    BARBARO, NM
    GUTIN, PH
    WILSON, CB
    SHELINE, GE
    BOLDREY, EB
    WARA, WM
    [J]. NEUROSURGERY, 1987, 20 (04) : 525 - 528
  • [2] H3K27me3 loss indicates an increased risk of recurrence in the Tubingen meningioma cohort
    Behling, Felix
    Fodi, Christina
    Gepfner-Tuma, Irina
    Kaltenbach, Kristina
    Renovanz, Mirjam
    Paulsen, Frank
    Skardelly, Marco
    Honegger, Juergen
    Tatagiba, Marcos
    Schittenhelm, Jens
    Tabatabai, Ghazaleh
    [J]. NEURO-ONCOLOGY, 2021, 23 (08) : 1273 - 1281
  • [3] The role of Simpson grading in meningiomas after integration of the updated WHO classification and adjuvant radiotherapy
    Behling, Felix
    Fodi, Christina
    Hoffmann, Elgin
    Renovanz, Mirjam
    Skardelly, Marco
    Tabatabai, Ghazaleh
    Schittenhelm, Jens
    Honegger, Jurgen
    Tatagiba, Marcos
    [J]. NEUROSURGICAL REVIEW, 2021, 44 (04) : 2329 - 2336
  • [4] Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis
    Cello, Gregory
    Patel, Ruchit V.
    McMahon, James Tanner
    Santagata, Sandro
    Bi, Wenya Linda
    [J]. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023, 11 (01)
  • [5] World Health Organization grade II meningiomas
    Champeaux, Charles
    Dunn, Laurence
    [J]. ACTA NEUROCHIRURGICA, 2016, 158 (05) : 921 - 929
  • [6] Day SE, 2017, CHIN CLIN ONCOL, V6, DOI 10.21037/cco.2017.06.01
  • [7] High Incidence of Activating TERT Promoter Mutations in Meningiomas Undergoing Malignant Progression
    Goutagny, Stephane
    Nault, Jean C.
    Mallet, Maxime
    Henin, Dominique
    Zucman-Rossi, Jessica
    Kalamarides, Michel
    [J]. BRAIN PATHOLOGY, 2014, 24 (02) : 184 - 189
  • [8] Meningiomas - transition from traditional histological grading to molecular profiling in WHO CNS5: A Review
    Goyal-Honavar, Abhijit
    Jayachandran, Ranjani
    Chacko, Geeta
    [J]. INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2022, 65 (05) : 83 - 93
  • [9] Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence
    Katz, Leah M.
    Hielscher, Thomas
    Liechty, Benjamin
    Silverman, Joshua
    Zagzag, David
    Sen, Rajeev
    Wu, Peter
    Golfinos, John G.
    Reuss, David
    Neidert, Marian Christoph
    Wirsching, Hans-Georg
    Baumgarten, Peter
    Herold-Mende, Christel
    Wick, Wolfgang
    Harter, Patrick N.
    Weller, Michael
    von Deimling, Andreas
    Snuderl, Matija
    Sen, Chandra
    Sahm, Felix
    [J]. ACTA NEUROPATHOLOGICA, 2018, 135 (06) : 955 - 963
  • [10] The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
    Louis, David N.
    Perry, Arie
    Wesseling, Pieter
    Brat, Daniel J.
    Cree, Ian A.
    Figarella-Branger, Dominique
    Hawkins, Cynthia
    Ng, H. K.
    Pfister, Stefan M.
    Reifenberger, Guido
    Soffietti, Riccardo
    von Deimling, Andreas
    Ellison, David W.
    [J]. NEURO-ONCOLOGY, 2021, 23 (08) : 1231 - 1251