Determinants of exercise capacity in patients with heart failure without left ventricular hypertrophy

被引：3

作者：

Ishizaka, Suguru ^{[1
,2
]}

Iwano, Hiroyuki ^{[1
,2
,3
]}

Tsujinaga, Shingo ^{[1
,2
]}

Murayama, Michito ^{[4
]}

Tsuneta, Satonori ^{[5
]}

Aoyagi, Hiroyuki ^{[1
,2
]}

Tamaki, Yoji ^{[1
,2
]}

Motoi, Ko ^{[1
,2
]}

Chiba, Yasuyuki ^{[1
,2
]}

Tanemura, Asuka ^{[4
]}

Nakabachi, Masahiro ^{[6
]}

Yokoyama, Shinobu ^{[6
]}

Nishino, Hisao ^{[6
]}

Okada, Kazunori ^{[7
]}

Meyers, Brett A. ^{[8
]}

Vlachos, Pavlos P. ^{[8
]}

Sato, Takuma ^{[1
,2
]}

Kamiya, Kiwamu ^{[1
,2
]}

Watanabe, Masaya ^{[1
,2
]}

Kaga, Sanae ^{[7
]}

Nagai, Toshiyuki ^{[1
,2
]}

Oyama-Manabe, Noriko ^{[9
]}

Anzai, Toshihisa ^{[1
,2
]}

机构：

[1] Hokkaido Univ, Fac Med, Dept Cardiovasc Med, Kita 15,Nishi 7,Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Grad Sch Med, Kita 15,Nishi 7,Kita Ku, Sapporo, Hokkaido 0608638, Japan

[3] Hakodate Municipal Hosp, Div Cardiol, Hakodate, Hokkaido, Japan

[4] Hokkaido Univ Hosp, Diagnost Ctr Sonog, Sapporo, Hokkaido, Japan

[5] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ Hosp, Div Clin Lab & Transfus Med, Sapporo, Hokkaido, Japan

[7] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido, Japan

[8] Purdue Univ, Sch Mech Engn, W Lafayette, IN USA

[9] Jichi Med Univ, Saitama Med Ctr, Dept Radiol, Saitama, Japan

来源：

JOURNAL OF CARDIOLOGY | 2023年 / 81卷 / 01期

基金：

日本学术振兴会;

关键词：

Exercise echocardiography; Pulmonary hypertension; Heart failure with preserved ejection fraction; Cardiac magnetic resonance; PRESERVED EJECTION FRACTION; EUROPEAN ASSOCIATION; DIASTOLIC FUNCTION; CARDIAC STRUCTURE; AMERICAN SOCIETY; PULMONARY-HYPERTENSION; EXTRACELLULAR VOLUME; ECHOCARDIOGRAPHY; RECOMMENDATIONS; INTOLERANCE;

D O I：

10.1016/j.jjcc.2022.09.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Determinants of exercise intolerance in a phenotype of heart failure with preserved ejection fraction (HFpEF) with normal left ventricular (LV) structure have not been fully elucidated. Methods: Cardiopulmonary exercise testing and exercise-stress echocardiography were performed in 44 HFpEF patients without LV hypertrophy. Exercise capacity was determined by peak oxygen consumption (peak VO2). Doppler-derived cardiac output (CO), transmitral E velocity, systolic (LV-s) and early diastolic mitral annular velocities (e), systolic pulmonary artery (PA) pressure (SPAP), tricuspid annular plane systolic excursion (TAPSE), and peak systolic right ventricular (RV) free wall velocity (RV-s) were measured at rest and exercise. E/e ' and TAPSE/SPAP were used as an LV filling pressure parameter and RV-PA coupling, respectively. Results: During exercise, CO, LV-s ', RV-s ', e ', and SPAP were significantly increased (p < 0.05 for all), whereas E/e ' remained unchanged and TAPSE/SPAP was significantly reduced (p < 0.001). SPAP was higher and TAPSE/SPAP was lower at peak exercise in patients showing lower-half peak VO2. In univariable analyses, LV-s ' (R = 0.35, p = 0.022), SPAP (R = -0.40, p = 0.008), RV-s ' (R = 0.47, p = 0.002), and TAPSE/SPAP (R = 0.42, p = 0.005) were significantly correlated with peak VO2. In multivariable analyses, not only SPAP, but also TAPSE/SPAP independently determined peak VO2 even after the adjustment for clinically relevant parameters. Conclusions: In HFpEF patients without LV hypertrophy, altered RV-PA coupling by exercise could be associated with exercise intolerance, which might not be caused by elevated LV filling pressure. (c) 2022 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

页码：33 / 41

页数：9

共 37 条

[1] Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction [J].