Nickel-catalysed C-N cross-coupling of organoboronic acids and isoxazoles

被引：1

作者：

Zhao, Yupeng ^{[1
]}

Wu, Changshu ^{[1
]}

Zhang, Jiaming ^{[1
]}

Gao, Yang ^{[1
,2
]}

Yuan, Zhuoxuan ^{[1
]}

Li, Xianwei ^{[1
]}

Chen, Qian ^{[1
]}

Huo, Yanping ^{[1
,2
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China

[2] Guangdong Lab, Jieyang Branch Chem & Chem Engn, Jieyang 515200, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 18期

基金：

中国国家自然科学基金;

关键词：

INTERMOLECULAR HYDROAMINATION; ASYMMETRIC HYDROGENATION; EFFICIENT SYNTHESIS; AMIDES; HALIDES; ALKYNES; ISOMERIZATION; ENAMINONES; ALKENES;

D O I：

10.1039/d4qo01050g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalysed C-N cross-coupling of organoboronic acids and isoxazoles has been established for the efficient synthesis of (Z) N-aryl beta-enamino esters. 5-Alkoxy/phenoxy isoxazoles serve as reliable aminating reagents in this transformation through N-O bond cleavage. A wide range of N-aryl beta-enamino esters (32 examples in up to 93% yields) with different functional groups were synthesized through this method under mild reaction conditions. A nickel-catalyzed C-N cross-coupling of organoboronic acids and isoxazoles has been established for the efficient synthesis of (Z) N-aryl beta-enamino esters.

引用

页码：5138 / 5143

页数：6

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