Differential Efficacy of Weight Loss Interventions in Patients with Versus Without Diabetes

被引：1

作者：

Losada-Diaz, Federico ^{[1
]}

Lizarazo-Bocanegra, Santiago ^{[1
]}

Perdomo-Lugo, Juan J. ^{[1
]}

Gutierrez-Romero, Sebastian A. ^{[1
]}

Correa-Osio, Isabella ^{[1
]}

Mendivil, Carlos O. ^{[1
,2
]}

机构：

[1] Univ Andes, Sch Med, Bogota, Colombia

[2] Fdn Santa Fe Bogota, Dept Internal Med, Sect Endocrinol, Bogota, Colombia

来源：

DIABETES THERAPY | 2024年 / 15卷 / 11期

关键词：

Obesity; Diabetes; Weight loss; GLP-1; agonists; Bariatric surgery; OBESE-PATIENTS; BODY-WEIGHT; BARIATRIC SURGERY; RECEPTOR AGONISTS; TYPE-2; OVERWEIGHT; ADULTS; LIRAGLUTIDE; SEMAGLUTIDE; LIFE;

D O I：

10.1007/s13300-024-01646-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is both a major risk factor for diabetes and a serious comorbidity of the condition. The twin epidemics of obesity and diabetes have spread globally over the past few decades. Treatment of obesity in patients with diabetes provides a host of clinical benefits that encompass virtually all body systems. Despite this, multiple lines of evidence suggest that the efficacy of most therapies for weight loss is significantly reduced among patients with diabetes. With this background, we summarize the evidence of a differential effect of lifestyle, pharmacological, and surgical treatments for obesity in patients with existing diabetes, and explore the potential mechanisms involved in this phenomenon. This information is then used to formulate strategies to improve weight loss outcomes for patients with diabetes.

引用

页码：2279 / 2291

页数：13

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