Genitourinary cancer and family: The reverberating psychological and cardiovascular effects of a genitourinary cancer diagnosis on first-degree relatives and spouses

被引：0

作者：

Choudry, Mouneeb M. ^{[1
]}

Murray, Nicole ^{[2
]}

Dindinger-Hill, Kassandra ^{[2
]}

Ambrose, Jacob ^{[3
,4
]}

Hunt, Trevor C. ^{[5
]}

Horns, Joshua ^{[1
]}

Martin, Christopher ^{[2
]}

Haaland, Benjamin ^{[3
,4
]}

Lowrance, William ^{[6
]}

Hanson, Heidi A. ^{[2
,3
,4
]}

Matern, Richard ^{[7
]}

Cartwright, Patrick C. ^{[2
,7
]}

O'Neil, Brock ^{[2
]}

机构：

[1] Mayo Clin, Dept Urol, Phoenix, AZ USA

[2] Univ Utah, Div Urol, 1950 Circle Hope Dr, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Surg, Salt Lake City, UT 84112 USA

[4] Univ Utah, Dept Populat Sci, Salt Lake City, UT 84112 USA

[5] Univ Rochester, Med Ctr, Dept Urol, Rochester, NY USA

[6] Bon Secours, Dept Urol, Easley, SC USA

[7] Intermt Healthcare, Salt Lake City, UT USA

来源：

CANCER | 2024年 / 130卷 / 23期

基金：

美国国家卫生研究院;

关键词：

cancer diagnosis; cardiovascular; family impact; first-degree relatives; psychological distress; spouse; CORONARY-HEART-DISEASE; CAREGIVING STRESS; INTERVENTIONS; DYSREGULATION; EPIDEMIOLOGY; DISTRESS; PARTNERS; PATIENT; BURDEN; COST;

D O I：

10.1002/cncr.35486

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThe psychological and cardiovascular health impacts on family members of patients who have been diagnosed with cancer have not been well characterized. The purpose of this study is to determine whether a family member's cancer diagnosis influences the risk of psychological illness and cardiovascular disease in first-degree relatives and spouses of patients affected by cancer.MethodsThis retrospective cohort analysis evaluated the risk of psychological illness and cardiovascular disease in first-degree relatives and spouses of patients diagnosed with a genitourinary cancer between 1990 and 2015 compared to relatives of those not diagnosed with a genitourinary cancer. The Utah Population Database was used and familial linkage was determined. Follow-up included 1-, 3-, and 5-year intervals. Patients residing outside of Utah and first-degree relatives and spouses with psychological or cardiovascular disease diagnosed before a family member's cancer diagnosis were excluded.ResultsA total of 49,284 patients with a genitourinary cancer were identified with 77,938 first-degree relatives and spouses. A matched control group included 246,775 patients with 81,022 first-degree relatives and spouses. Via Cox proportional hazards models, a 10% increased risk of developing a psychological illness (hazard ratio [HR], 1.10; 95% CI, 1.00-1.20) and a 28% increased risk of developing cardiovascular disease (HR, 1.28; 95% CI, 1.17-1.41) at 1 year after a family member's cancer diagnosis were found.ConclusionsThis study provides population-level evidence to support the hypothesis that cancer diagnoses will lead to adverse health outcomes for family members of patients with cancer. Increased clinical attention and support are needed to reduce the harm to families caused by cancer. The purpose of this study is to determine whether a family member's cancer diagnosis influences the risk of psychological illness and cardiovascular disease in first-degree relatives and spouses of patients affected by cancer.

引用

页码：4061 / 4070

页数：10

共 43 条

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