Multiomics approaches to uncover endometrial receptivity in embryo implantation: a mini-review

Successful implantation requires concerted interactions during the apposition, adhesion, and invasion of the embryo into a receptive endometrium. However, the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality embryos. Changes in endometrial transcriptomics, proteomics, lipidomics, and even microbiota all play important roles in embryo implantation. Specifically, the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense research. This review (a) summarizes the different molecules expressed in the receptive endometrium and (b) proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.