Circadian disruptions and their role in the development of hypertension

被引:0
作者
Crowthers, Raymond [1 ]
Nguyen, Trinh Thi Mong [1 ]
Martinez, Diana [1 ]
机构
[1] Rowan Univ, Dept Biomed Sci, Cooper Med Sch, Camden, NJ 08102 USA
关键词
synaptic transmission; circadian system; autonomic nervous system; hypertension; circadian misalignment; shift work; social jetlag; sleep; NOCTURNAL BLOOD-PRESSURE; SUPRACHIASMATIC NUCLEUS; SHIFT WORK; SOCIAL JETLAG; HEART-RATE; CARDIOVASCULAR-DISEASE; PARAVENTRICULAR NUCLEUS; NEIGHBORHOOD PROBLEMS; SOCIOECONOMIC-STATUS; ETHNIC-DIFFERENCES;
D O I
10.3389/fnins.2024.1433512
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Circadian fluctuations in physiological setpoints are determined by the suprachiasmatic nucleus (SCN) which exerts control over many target structures within and beyond the hypothalamus via projections. The SCN, or central pacemaker, orchestrates synchrony between the external environment and the internal circadian mechanism. The resulting cycles in hormone levels and autonomic nervous system (ANS) activity provide precise messages to specific organs, adjusting, for example, their sensitivity to approaching hormones or metabolites. The SCN responds to both photic (light) and non-photic input. Circadian patterns are found in both heart rate and blood pressure, which are linked to daily variations in activity and autonomic nervous system activity. Variations in blood pressure are of great interest as several cardiovascular diseases such as stroke, arrhythmias, and hypertension are linked to circadian rhythm dysregulation. The disruption of normal day-night cycles, such as in shift work, social jetlag, or eating outside of normal hours leads to desynchronization of the central and peripheral clocks. This desynchronization leads to disorganization of the cellular processes that are normally driven by the interactions of the SCN and photic input. Here, we review autonomic system function and dysfunction due to regulation and interaction between different cardiorespiratory brain centers and the SCN, as well as social, lifestyle, and external factors that may impact the circadian control of blood pressure.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] The Childhood Role in Development of Primary Hypertension
    Falkner, Bonita
    AMERICAN JOURNAL OF HYPERTENSION, 2018, 31 (07) : 762 - 769
  • [32] Circadian rhythm development in preterm infants. The role of postnatal versus postmenstrual age
    Govindan, R. B.
    Andescavage, Nickie N.
    Basu, Sudeepta
    Murnick, Jonathan
    Ngwa, Julius
    Galla, Jeffrey T.
    Kapse, Kushal
    Limperopoulos, Catherine
    du Plessis, Adre
    EARLY HUMAN DEVELOPMENT, 2024, 196
  • [33] The Role of Vascular Aging in the Development of Hypertension
    Heredia, Celia Pena
    Furman, Deborah
    Moreno, Denisse G.
    Tuday, Eric
    CLINICS IN GERIATRIC MEDICINE, 2024, 40 (04) : 539 - 550
  • [34] Development of the circadian system in early life: maternal and environmental factors
    Wong, Sachi D.
    Wright, Kenneth P., Jr.
    Spencer, Robert L.
    Vetter, Celine
    Hicks, Laurel M.
    Jenni, Oskar G.
    LeBourgeois, Monique K.
    JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 2022, 41 (01)
  • [35] Circadian glucocorticoids throughout development
    Lehmann, Marianne
    Haury, Katharina
    Oster, Henrik
    Astiz, Mariana
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [36] Is uncontrolled hypertension related to sleep quality and circadian rhythm?
    Kazemi, Erfan
    Abadi, Mahshad Naeim
    Shirvani, Yeganeh Ebrahimnia
    Moghbeli, Golnush
    Enayatrad, Mostafa
    Sheibani, Hossein
    BIOLOGICAL RHYTHM RESEARCH, 2024, 55 (02) : 123 - 134
  • [37] The connection between hypertension and diabetes and their role in heart and kidney disease development
    Hezam, Ali Ahmed Mohammed
    Shaghdar, Hanan Basheer Mohammed
    Chen, Liying
    JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2024, 29 (01):
  • [38] The Role and Mechanism of Intestinal Flora in Blood Pressure Regulation and Hypertension Development
    Li, Jing
    Yang, Xinchun
    Zhou, Xin
    Cai, Jun
    ANTIOXIDANTS & REDOX SIGNALING, 2021, 34 (10) : 811 - 830
  • [39] Cell "circadian" cycle New role for mammalian core clock genes
    Borgs, Laurence
    Beukelaers, Pierre
    Vandenbosch, Renaud
    Belachew, Shibeshih
    Nguyen, Laurent
    Malgrange, Brigitte
    CELL CYCLE, 2009, 8 (06) : 832 - 837
  • [40] The role of the cardiomyocyte circadian clocks in ion channel regulation and cardiac electrophysiology
    Schroder, Elizabeth A.
    Ono, Makoto
    Johnson, Sidney R.
    Rozmus, Ezekiel R.
    Burgess, Don E.
    Esser, Karyn A.
    Delisle, Brian P.
    JOURNAL OF PHYSIOLOGY-LONDON, 2022, 600 (09): : 2037 - 2048