Circadian disruptions and their role in the development of hypertension

被引:0
|
作者
Crowthers, Raymond [1 ]
Nguyen, Trinh Thi Mong [1 ]
Martinez, Diana [1 ]
机构
[1] Rowan Univ, Dept Biomed Sci, Cooper Med Sch, Camden, NJ 08102 USA
关键词
synaptic transmission; circadian system; autonomic nervous system; hypertension; circadian misalignment; shift work; social jetlag; sleep; NOCTURNAL BLOOD-PRESSURE; SUPRACHIASMATIC NUCLEUS; SHIFT WORK; SOCIAL JETLAG; HEART-RATE; CARDIOVASCULAR-DISEASE; PARAVENTRICULAR NUCLEUS; NEIGHBORHOOD PROBLEMS; SOCIOECONOMIC-STATUS; ETHNIC-DIFFERENCES;
D O I
10.3389/fnins.2024.1433512
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Circadian fluctuations in physiological setpoints are determined by the suprachiasmatic nucleus (SCN) which exerts control over many target structures within and beyond the hypothalamus via projections. The SCN, or central pacemaker, orchestrates synchrony between the external environment and the internal circadian mechanism. The resulting cycles in hormone levels and autonomic nervous system (ANS) activity provide precise messages to specific organs, adjusting, for example, their sensitivity to approaching hormones or metabolites. The SCN responds to both photic (light) and non-photic input. Circadian patterns are found in both heart rate and blood pressure, which are linked to daily variations in activity and autonomic nervous system activity. Variations in blood pressure are of great interest as several cardiovascular diseases such as stroke, arrhythmias, and hypertension are linked to circadian rhythm dysregulation. The disruption of normal day-night cycles, such as in shift work, social jetlag, or eating outside of normal hours leads to desynchronization of the central and peripheral clocks. This desynchronization leads to disorganization of the cellular processes that are normally driven by the interactions of the SCN and photic input. Here, we review autonomic system function and dysfunction due to regulation and interaction between different cardiorespiratory brain centers and the SCN, as well as social, lifestyle, and external factors that may impact the circadian control of blood pressure.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] The role of race and ethnicity in sleep, circadian rhythms and cardiovascular health
    Egan, Kieren J.
    Knutson, Kristen L.
    Pereira, Alexandre C.
    von Schantz, Malcolm
    SLEEP MEDICINE REVIEWS, 2017, 33 : 70 - 78
  • [2] Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
    Li, Xiaohong
    He, Yanjin
    Wang, Dawu
    Momeni, Mohammad Reza
    CLINICAL AND EXPERIMENTAL MEDICINE, 2024, 25 (01)
  • [3] Circadian regulation of renal function and potential role in hypertension
    Bonny, Olivier
    Firsov, Dmitri
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2013, 22 (04) : 439 - 444
  • [4] Role of the circadian system in cardiovascular disease
    Thosar, Saurabh S.
    Butler, Matthew P.
    Shea, Steven A.
    JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (06) : 2157 - 2167
  • [5] The role of the circadian system in fractal neurophysiological control
    Pittman-Polletta, Benjamin R.
    Scheer, Frank A. J. L.
    Butler, Matthew P.
    Shea, Steven A.
    Hu, Kun
    BIOLOGICAL REVIEWS, 2013, 88 (04) : 873 - 894
  • [6] Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension
    Costello, Hannah M.
    Gumz, Michelle L.
    HYPERTENSION, 2021, 78 (05) : 1185 - 1196
  • [7] Neurochemical and Neuropharmacological Aspects of Circadian Disruptions: An Introduction to Asynchronization
    Kohyama, Jun
    CURRENT NEUROPHARMACOLOGY, 2011, 9 (02) : 330 - 341
  • [8] Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension
    Costello, Hannah M.
    Sharma, Ravindra K.
    Mckee, Annalisse R.
    Gumz, Michelle L.
    CANADIAN JOURNAL OF CARDIOLOGY, 2023, 39 (12) : 1757 - 1771
  • [9] Development of circadian rhythms: Role of postnatal light environment
    Brooks, Elisabeth
    Canal, Maria M.
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2013, 37 (04) : 551 - 560
  • [10] Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide
    Schroeder, Analyne
    Loh, Dawn H.
    Jordan, Maria C.
    Roos, Kenneth P.
    Colwell, Christopher S.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (01): : H241 - H250