Daphnetin modulates GLP-1R to alleviate cognitive dysfunction in diabetes: implications for inflammation and oxidative stress

被引：2
作者：
Liang, Feng [1 ]
Tian, Xinyi [2 ]
Ding, Lining [2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Clin Lab, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China
[2] Northwest A&F Univ, Coll Chem & Pharm, Xianyang, Peoples R China
[3] Guangdong Pharmaceut Univ, Guangzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
daphnetin; diabetes cognitive dysfunction; pharmacological effects; GLP-1; receptor; inflammation and oxidative stress; MELLITUS; AGONISTS;
D O I：
10.3389/fphar.2024.1438926
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Daphnetin exerts certain pharmacological function on a variety of diseases, but its role in diabetic cognitive dysfunction has not been elucidated. In this study, we carried a series of pharmacological studies of GLP-1R with daphnetin. In rats and PC12 cells, we found that daphnetin could alleviate diabetic cognitive dysfunction and increase the expression level of GLP-1R. Additionally, the anti-diabetic cognitive dysfunction effect of DAP was accompanied by the inhibition of inflammation and oxidative stress. Further in-depth studies demonstrated that the inhibition GLP-1R enhanced the protective effect of daphnetin, whilst, the overexpression of GLP-1R weakened the protective effect of daphnetin. These results indicated that daphnetin protects diabetes cognitive dysfunction by regulating GLP-1R-mediated inflammation and oxidative stress, act as a GLP-1R agonist. The study further demonstrated that daphnetin has great value in preventing cognitive dysfunction in type 2 diabetes, and GLP-1R is a key potential target for the treatment of related diseases.
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页数：11
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