Daphnetin modulates GLP-1R to alleviate cognitive dysfunction in diabetes: implications for inflammation and oxidative stress

被引:1
|
作者
Liang, Feng [1 ]
Tian, Xinyi [2 ]
Ding, Lining [2 ,3 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Clin Lab, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China
[2] Northwest A&F Univ, Coll Chem & Pharm, Xianyang, Peoples R China
[3] Guangdong Pharmaceut Univ, Guangzhou, Peoples R China
关键词
daphnetin; diabetes cognitive dysfunction; pharmacological effects; GLP-1; receptor; inflammation and oxidative stress; MELLITUS; AGONISTS;
D O I
10.3389/fphar.2024.1438926
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Daphnetin exerts certain pharmacological function on a variety of diseases, but its role in diabetic cognitive dysfunction has not been elucidated. In this study, we carried a series of pharmacological studies of GLP-1R with daphnetin. In rats and PC12 cells, we found that daphnetin could alleviate diabetic cognitive dysfunction and increase the expression level of GLP-1R. Additionally, the anti-diabetic cognitive dysfunction effect of DAP was accompanied by the inhibition of inflammation and oxidative stress. Further in-depth studies demonstrated that the inhibition GLP-1R enhanced the protective effect of daphnetin, whilst, the overexpression of GLP-1R weakened the protective effect of daphnetin. These results indicated that daphnetin protects diabetes cognitive dysfunction by regulating GLP-1R-mediated inflammation and oxidative stress, act as a GLP-1R agonist. The study further demonstrated that daphnetin has great value in preventing cognitive dysfunction in type 2 diabetes, and GLP-1R is a key potential target for the treatment of related diseases.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Mollugin activates GLP-1R to improve cognitive dysfunction in type 2 diabetic mice
    Wang, Zhuanzhuan
    Cui, Xin
    Yan, Wenhui
    Liu, Na
    Shang, Jia
    Yi, Xinyao
    Guo, Tingli
    Wei, Xiaotong
    Sun, Yuzhuo
    Hu, Hao
    Ma, Weina
    Cui, Wei
    Chen, Lina
    LIFE SCIENCES, 2023, 331
  • [2] Baicalein: A potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
    Liu, Na
    Cui, Xin
    Yan, Wenhui
    Guo, Tingli
    Wang, Zhuanzhuan
    Wei, Xiaotong
    Sun, Yuzhuo
    Liu, Jieyun
    Xian, Cheng
    Ma, Weina
    Chen, Lina
    JOURNAL OF PHARMACEUTICAL ANALYSIS, 2024, 14 (08)
  • [3] Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
    Dludla, Phiwayinkosi, V
    Mabhida, Sihle E.
    Ziqubu, Khanyisani
    Nkambule, Bongani B.
    Mazibuko-Mbeje, Sithandiwe E.
    Hanser, Sidney
    Basson, Albert Kotze
    Pheiffer, Carmen
    Kengne, Andre Pascal
    WORLD JOURNAL OF DIABETES, 2023, 14 (03)
  • [4] CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin
    Coskun, Zeynep Mine
    Koyuturk, Meral
    Karabulut, Sezin
    Bolkent, Sema
    PHARMACOLOGICAL REPORTS, 2017, 69 (04) : 822 - 829
  • [5] GLP-1R agonist therapy and vaccine response: Neglected implications
    van Niekerk, Gustav
    Coelmont, Lotte
    Alpizar, Yeranddy A.
    Kelchtermans, Lara
    Broeckhoven, Elias
    Dallmeier, Kai
    CYTOKINE & GROWTH FACTOR REVIEWS, 2024, 78 : 14 - 24
  • [6] GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner
    Trammell, Taylor S.
    Henderson, Natalie L.
    Madkour, Haley S.
    Stanwood, Gregg D.
    Graham, Devon L.
    NEUROLOGICAL SCIENCES, 2021, 42 (07) : 2911 - 2919
  • [7] Immunomodulation and inflammation: Role of GLP-1R and GIPR expressing cells within the gut
    Morrow, Nadya M.
    Morissette, Arianne
    Mulvihill, Erin E.
    PEPTIDES, 2024, 176
  • [8] Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation
    Wu, Ying
    Song, Meiyan
    Chen, Wen
    Xu, Kaizu
    Wu, Meifang
    Lin, Liming
    REDOX REPORT, 2023, 28 (01)
  • [9] Chronic cold stress promotes inflammation and ER stress via inhibiting GLP-1R signaling, and exacerbates the risk of ferroptosis in the liver and pancreas
    Teng, Teng
    Zheng, Yusong
    Zhang, Mengqi
    Sun, Guodong
    Li, Zhongyu
    Shi, Baoming
    Shang, Tingting
    ENVIRONMENTAL POLLUTION, 2024, 360
  • [10] GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner
    Taylor S. Trammell
    Natalie L. Henderson
    Haley S. Madkour
    Gregg D. Stanwood
    Devon L. Graham
    Neurological Sciences, 2021, 42 : 2911 - 2919