Targeting CD38 with isatuximab and a novel CD38/CD3xCD28 trispecific T-cell engager in older patients with acute myeloid leukemia

被引:2
作者
Martin-Sanchez, Esperanza [1 ]
Blanco, Laura [1 ]
Kim, Peter S. [2 ]
Bisht, Kamlesh [2 ]
Wang, Hongfang [2 ]
van de Velde, Helgi [2 ]
Jelinek, Tomas [1 ,3 ,4 ]
Simoes, Catia [1 ]
Prosper, Felipe [1 ]
Miguel, Jesus F. San [1 ]
Alfonso, Ana [1 ]
Bergua, Juan [5 ]
Rodriguez-Veiga, Rebeca [6 ]
Vives, Susana [7 ]
Martinez-Cuadron, David [6 ,7 ]
Montesinos, Pau [6 ,7 ]
Paiva, Bruno [1 ]
Zabaleta, Aintzane [1 ]
机构
[1] Clin Univ Navarra, Inst Invest Sanit Navarra, Ctr Invest Med Aplicada, Canc Ctr,CIBER ONC Numbers CB16 12 00369 & CB16 12, Pamplona, Spain
[2] Sanofi R&D, North Amer, Cambridge, MA USA
[3] Univ Ostrava, Univ Hosp Ostrava, Dept Hematooncol, Ostrava, Czech Republic
[4] Univ Ostrava, Fac Med, Ostrava, Czech Republic
[5] Hosp San Pedro Alcantara, Caceres, Spain
[6] Hosp Univ La Fe, Valencia, Spain
[7] Hosp Germans Trias I Pujol, Josep Carreras Res Inst, Inst Catala Oncol Badalona, Badalona, Spain
关键词
OPEN-LABEL; DEXAMETHASONE; DARATUMUMAB; LENALIDOMIDE; EXPRESSION; TREAT;
D O I
10.1182/bloodadvances.2024013212
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:3875 / 3879
页数:5
相关论文
共 25 条
  • [1] Anti-Acute Myeloid Leukemia Activity of CD38-CAR-T Cells with PI3K? Downregulation
    An, Na
    Pan, Yuming
    Yang, Linlin
    Zhang, Qiongli
    Deng, Sisi
    Zhang, Qiaoxia
    Du, Xin
    [J]. MOLECULAR PHARMACEUTICS, 2023, 20 (05) : 2426 - 2435
  • [2] Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
    Attal, Michel
    Richardson, Paul G.
    Rajkumar, S. Vincent
    San-Miguel, Jesus
    Beksac, Meral
    Spicka, Ivan
    Leleu, Xavier
    Schjesvold, Fredrik
    Moreau, Philippe
    Dimopoulos, Meletios A.
    Huang, Jeffrey Shang-Yi
    Minarik, Jiri
    Cavo, Michele
    Prince, H. Miles
    Mace, Sandrine
    Corzo, Kathryn P.
    Campana, Frank
    Le-Guennec, Solenn
    Dubin, Franck
    Anderson, Kenneth C.
    [J]. LANCET, 2019, 394 (10214) : 2096 - 2107
  • [3] CD38-directed CAR-T cell therapy: a novel immunotherapy strategy for relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
    Cui, Qingya
    Qian, Chongsheng
    Xu, Nan
    Kang, Liqing
    Dai, Haiping
    Cui, Wei
    Song, Baoquan
    Yin, Jia
    Li, Zheng
    Zhu, Xiaming
    Qu, Changju
    Liu, Tianhui
    Shen, Wenhong
    Zhu, Mingqing
    Yu, Lei
    Wu, Depei
    Tang, Xiaowen
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [4] T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments
    Daver, Naval
    Alotaibi, Ahmad S.
    Bucklein, Veit
    Subklewe, Marion
    [J]. LEUKEMIA, 2021, 35 (07) : 1843 - 1863
  • [5] Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma
    Dimopoulos, M. A.
    Oriol, A.
    Nahi, H.
    San-Miguel, J.
    Bahlis, N. J.
    Usmani, S. Z.
    Rabin, N.
    Orlowski, R. Z.
    Komarnicki, M.
    Suzuki, K.
    Plesner, T.
    Yoon, S. -S.
    Ben Yehuda, D.
    Richardson, P. G.
    Goldschmidt, H.
    Reece, D.
    Lisby, S.
    Khokhar, N. Z.
    O'Rourke, L.
    Chiu, C.
    Qin, X.
    Guckert, M.
    Ahmadi, T.
    Moreau, P.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (14) : 1319 - 1331
  • [6] Dimopoulos MA, 2021, LANCET ONCOL, V22, P801, DOI 10.1016/S1470-2045(21)00128-5
  • [7] How I treat acute myeloid leukemia in the era of new drugs
    DiNardo, Courtney D.
    Wei, Andrew H.
    [J]. BLOOD, 2020, 135 (02) : 85 - 96
  • [8] Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma
    Facon, T.
    Kumar, S.
    Plesner, T.
    Orlowski, R. Z.
    Moreau, P.
    Bahlis, N.
    Basu, S.
    Nahi, H.
    Hulin, C.
    Quach, H.
    Goldschmidt, H.
    O'Dwyer, M.
    Perrot, A.
    Venner, C. P.
    Weisel, K.
    Mace, J. R.
    Raje, N.
    Attal, M.
    Tiab, M.
    Macro, M.
    Frenzel, L.
    Leleu, X.
    Ahmadi, T.
    Chiu, C.
    Wang, J.
    Van Rampelbergh, R.
    Uhlar, C. M.
    Kobos, R.
    Qi, M.
    Usmani, S. Z.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (22) : 2104 - 2115
  • [9] CD38 as a pan-hematologic target for chimeric antigen receptor T cells
    Glisovic-Aplenc, Tina
    Diorio, Caroline
    Chukinas, John A.
    Veliz, Kimberly
    Shestova, Olga
    Shen, Feng
    Nunez-Cruz, Selene
    Vincent, Tiffaney L.
    Miao, Fei
    Milone, Michael C.
    June, Carl H.
    Teachey, David T.
    Tasian, Sarah K.
    Aplenc, Richard
    Gill, Saar
    [J]. BLOOD ADVANCES, 2023, 7 (16) : 4418 - 4430
  • [10] Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry
    Juliusson, Gunnar
    Antunovic, Petar
    Derolf, Asa
    Lehmann, Soren
    Mollgard, Lars
    Stockelberg, Dick
    Tidefelt, Ulf
    Wahlin, Anders
    Hoglund, Martin
    [J]. BLOOD, 2009, 113 (18) : 4179 - 4187