Targeting CD38 with isatuximab and a novel CD38/CD3xCD28 trispecific T-cell engager in older patients with acute myeloid leukemia

被引：4

作者：

Martin-Sanchez, Esperanza ^{[1
]}

Blanco, Laura ^{[1
]}

Kim, Peter S. ^{[2
]}

Bisht, Kamlesh ^{[2
]}

Wang, Hongfang ^{[2
]}

van de Velde, Helgi ^{[2
]}

Jelinek, Tomas ^{[1
,3
,4
]}

Simoes, Catia ^{[1
]}

Prosper, Felipe ^{[1
]}

Miguel, Jesus F. San ^{[1
]}

Alfonso, Ana ^{[1
]}

Bergua, Juan ^{[5
]}

Rodriguez-Veiga, Rebeca ^{[6
]}

Vives, Susana ^{[7
]}

Martinez-Cuadron, David ^{[6
,7
]}

Montesinos, Pau ^{[6
,7
]}

Paiva, Bruno ^{[1
]}

Zabaleta, Aintzane ^{[1
]}

机构：

[1] Clin Univ Navarra, Inst Invest Sanit Navarra, Ctr Invest Med Aplicada, Canc Ctr,CIBER ONC Numbers CB16 12 00369 & CB16 12, Pamplona, Spain

[2] Sanofi R&D, North Amer, Cambridge, MA USA

[3] Univ Ostrava, Univ Hosp Ostrava, Dept Hematooncol, Ostrava, Czech Republic

[4] Univ Ostrava, Fac Med, Ostrava, Czech Republic

[5] Hosp San Pedro Alcantara, Caceres, Spain

[6] Hosp Univ La Fe, Valencia, Spain

[7] Hosp Germans Trias I Pujol, Josep Carreras Res Inst, Inst Catala Oncol Badalona, Badalona, Spain

来源：

BLOOD ADVANCES | 2024年 / 8卷 / 15期

关键词：

OPEN-LABEL; DEXAMETHASONE; DARATUMUMAB; LENALIDOMIDE; EXPRESSION; TREAT;

D O I：

10.1182/bloodadvances.2024013212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：3875 / 3879

页数：5

共 24 条

[1] Anti-Acute Myeloid Leukemia Activity of CD38-CAR-T Cells with PI3K? Downregulation [J].

An, Na ;

Pan, Yuming ;

Yang, Linlin ;

Zhang, Qiongli ;

Deng, Sisi ;

Zhang, Qiaoxia ;

Du, Xin .

MOLECULAR PHARMACEUTICS, 2023, 20 (05) :2426-2435

[2] CD38-directed CAR-T cell therapy: a novel immunotherapy strategy for relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation [J].

Cui, Qingya ;

Qian, Chongsheng ;

Xu, Nan ;

Kang, Liqing ;

Dai, Haiping ;

Cui, Wei ;

Song, Baoquan ;

Yin, Jia ;

Li, Zheng ;

Zhu, Xiaming ;

Qu, Changju ;

Liu, Tianhui ;

Shen, Wenhong ;

Zhu, Mingqing ;

Yu, Lei ;

Wu, Depei ;

Tang, Xiaowen .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)

[3] T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments [J].

Daver, Naval ;

Alotaibi, Ahmad S. ;

Bucklein, Veit ;

Subklewe, Marion .

LEUKEMIA, 2021, 35 (07) :1843-1863

[4] Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma [J].

Dimopoulos, M. A. ;

Oriol, A. ;

Nahi, H. ;

San-Miguel, J. ;

Bahlis, N. J. ;

Usmani, S. Z. ;

Rabin, N. ;

Orlowski, R. Z. ;

Komarnicki, M. ;

Suzuki, K. ;

Plesner, T. ;

Yoon, S. -S. ;

Ben Yehuda, D. ;

Richardson, P. G. ;

Goldschmidt, H. ;

Reece, D. ;

Lisby, S. ;

Khokhar, N. Z. ;

O'Rourke, L. ;

Chiu, C. ;

Qin, X. ;

Guckert, M. ;

Ahmadi, T. ;

Moreau, P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (14) :1319-1331

[5]

Dimopoulos MA, 2021, LANCET ONCOL, V22, P801, DOI 10.1016/S1470-2045(21)00128-5

[6] How I treat acute myeloid leukemia in the era of new drugs [J].

DiNardo, Courtney D. ;

Wei, Andrew H. .

BLOOD, 2020, 135 (02) :85-96

[7] Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma [J].

Facon, T. ;

Kumar, S. ;

Plesner, T. ;

Orlowski, R. Z. ;

Moreau, P. ;

Bahlis, N. ;

Basu, S. ;

Nahi, H. ;

Hulin, C. ;

Quach, H. ;

Goldschmidt, H. ;

O'Dwyer, M. ;

Perrot, A. ;

Venner, C. P. ;

Weisel, K. ;

Mace, J. R. ;

Raje, N. ;

Attal, M. ;

Tiab, M. ;

Macro, M. ;

Frenzel, L. ;

Leleu, X. ;

Ahmadi, T. ;

Chiu, C. ;

Wang, J. ;

Van Rampelbergh, R. ;

Uhlar, C. M. ;

Kobos, R. ;

Qi, M. ;

Usmani, S. Z. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (22) :2104-2115

[8] CD38 as a pan-hematologic target for chimeric antigen receptor T cells [J].

Glisovic-Aplenc, Tina ;

Diorio, Caroline ;

Chukinas, John A. ;

Veliz, Kimberly ;

Shestova, Olga ;

Shen, Feng ;

Nunez-Cruz, Selene ;

Vincent, Tiffaney L. ;

Miao, Fei ;

Milone, Michael C. ;

June, Carl H. ;

Teachey, David T. ;

Tasian, Sarah K. ;

Aplenc, Richard ;

Gill, Saar .

BLOOD ADVANCES, 2023, 7 (16) :4418-4430

[9] Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry [J].

Juliusson, Gunnar ;

Antunovic, Petar ;

Derolf, Asa ;

Lehmann, Soren ;

Mollgard, Lars ;

Stockelberg, Dick ;

Tidefelt, Ulf ;

Wahlin, Anders ;

Hoglund, Martin .

BLOOD, 2009, 113 (18) :4179-4187

[10] EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols [J].

Kalina, T. ;

Flores-Montero, J. ;

van der Velden, V. H. J. ;

Martin-Ayuso, M. ;

Boettcher, S. ;

Ritgen, M. ;

Almeida, J. ;

Lhermitte, L. ;

Asnafi, V. ;

Mendonca, A. ;

de Tute, R. ;

Cullen, M. ;

Sedek, L. ;

Vidriales, M. B. ;

Perez, J. J. ;

te Marvelde, J. G. ;

Mejstrikova, E. ;

Hrusak, O. ;

Szczepanski, T. ;

van Dongen, J. J. M. ;

Orfao, A. .

LEUKEMIA, 2012, 26 (09) :1986-2010

← 1 2 3 →