Renalase Potential as a Marker and Therapeutic Target in Chronic Kidney Disease

被引：0
作者：
Serban-Feier, Larisa Florina [1 ,2 ]
Cuiban, Elena [1 ,2 ]
Gogosoiu, Elena Bianca [2 ]
Stepan, Elena [1 ]
Radulescu, Daniela [1 ,2 ]
机构：
[1] Carol Davila Univ Med & Pharm, Fac Med, Dept Nephrol, Bucharest 020021, Romania
[2] Sfantul Ioan Clin Emergency Hosp, Dept Nephrol, Bucharest 042122, Romania
来源：
BIOMEDICINES | 2024年 / 12卷 / 08期
关键词：
renalase; hypertension; cardiovascular disease; chronic kidney disease; PERITONEAL-DIALYSIS PATIENTS; INCREASED SERUM RENALASE; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; ALL-CAUSE; CATECHOLAMINES; HYPERTENSION; DOPAMINE; NOREPINEPHRINE;
D O I：
10.3390/biomedicines12081715
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hypertension and cardiovascular disease are prominent features of chronic kidney disease, and they are associated with premature mortality and progression toward end-stage kidney disease. Renalase, an enzyme secreted predominantly by the kidney and identified in 2005, seems to be one of the missing pieces in the puzzle of heart and kidney interaction in chronic kidney disease by lowering blood pressure and reducing the overactivity of sympathetic tone. This review aims to summarize evidence from clinical studies performed on subjects with CKD in order to explore the value of renalase as a marker and/or a therapeutic target in this disease.
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页数：12
相关论文
共 66 条
  • [1] Al-Shamma Z.A.A., 2018, Asian J. Pharm. Clin. Res, V11, P313, DOI [10.22159/ajpcr.2018.v11i2.22778, DOI 10.22159/AJPCR.2018.V11I2.22778]
  • [2] Cardioprotective Effect of Renalase in 5/6 Nephrectomized Rats
    Baraka, A.
    El Ghotny, S.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2012, 17 (04) : 412 - 416
  • [3] Rena lase does not catalyze the oxidation of catecholamines
    Beaupre, Brett A.
    Hoag, Matthew R.
    Moran, Graham R.
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015, 579 : 62 - 66
  • [4] Major pathways of the reno-cardiovascular link: the sympathetic and renin-angiotensin systems
    Blankestijn, Peter J.
    London, Gerard
    Fliser, Danilo
    Jager, Kitty J.
    Lindholm, Bengt
    Goldsmith, David
    Wiecek, Andrzej
    Suleymanlar, Gultekin
    Agarwal, Rajiv
    Ortiz, Alberto
    Massy, Ziad
    Martinez-Castelao, Alberto
    Covic, Adrian
    Dekker, Friedo W.
    Zoccali, Carmine
    [J]. KIDNEY INTERNATIONAL SUPPLEMENTS, 2011, 1 (01): : 13 - 16
  • [5] Renalase, a catecholamine-metabolising enzyme?
    Boomsma, F.
    Tipton, K. F.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (06) : 775 - 776
  • [6] Circulating Renalase as Predictor of Renal and Cardiovascular Outcomes in Pre-Dialysis CKD Patients: A 5-Year Prospective Cohort Study
    Cerqueira, Ana
    Quelhas-Santos, Janete
    Ferreira, Ines
    Sampaio, Susana
    Relvas, Miguel
    Marques, Nidia
    Dias, Claudia Camila
    Pestana, Manuel
    [J]. LIFE-BASEL, 2021, 11 (03): : 1 - 12
  • [7] RENALASE, RENAL FUNCTION AND BIOMARKERS OF ENDOTHELIAL DYSFUNCTION IN CHRONIC KIDNEY DISEASE PATIENTS
    Cerqueira, Ana
    Santos, Janete Quelhas
    Martins, Sandra
    Dias, Margarida Sarmento
    Pestana, Manuel
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30
  • [8] Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality
    Chang, J.
    Guo, X.
    Rao, V
    Gromisch, E. S.
    Chung, S.
    Kluger, H. M.
    Cha, C.
    Gorelick, F.
    Testani, J.
    Safirstein, R.
    Crowley, S.
    Peixoto, A. J.
    Desir, G., V
    [J]. KIDNEY INTERNATIONAL REPORTS, 2020, 5 (03): : 362 - 368
  • [9] SYMPATHETIC OVERACTIVITY IN PATIENTS WITH CHRONIC-RENAL-FAILURE
    CONVERSE, RL
    JACOBSEN, TN
    TOTO, RD
    JOST, CMT
    COSENTINO, F
    FOUADTARAZI, F
    VICTOR, RG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (27) : 1912 - 1918
  • [10] Desir G., 2019, KI Rep, V41, pS84, DOI [10.1016/j.ekir.2019.05.217, DOI 10.1016/J.EKIR.2019.05.217]
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