High-frequency repetitive transcranial magnetic stimulation promotes ipsilesional functional hyperemia and motor recovery in mice with ischemic stroke

被引：2
作者：
Liu, Li [1 ]
Ding, Ming [1 ,2 ]
Wu, Junfa [1 ]
Zhang, Yuwen [3 ]
Wang, Qianfeng [3 ]
Wang, Nianhong [1 ]
Luo, Lu [1 ]
Yu, Kewei [1 ]
Fan, Yunhui [1 ]
Zhang, Jingjun [1 ]
Wu, Yi [1 ]
Xiao, Xiao [2 ]
Zhang, Qun [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Rehabil Med, Shanghai 200040, Peoples R China
[2] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Behav & Cognit Neurosci Ctr, Shanghai, Peoples R China
[3] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
来源：
CEREBRAL CORTEX | 2024年 / 34卷 / 03期
基金：
国家重点研发计划;
关键词：
cerebral blood flow; functional hyperemia; MRS; neuronal metabolic; rTMS; CEREBRAL-BLOOD-FLOW; BRAIN;
D O I：
10.1093/cercor/bhae074
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurovascular decoupling plays a significant role in dysfunction following an ischemic stroke. This study aimed to explore the effect of low- and high-frequency repetitive transcranial magnetic stimulation on neurovascular remodeling after ischemic stroke. To achieve this goal, we compared functional hyperemia, cerebral blood flow regulatory factors, and neurochemical transmitters in the peri-infract cortex 21 days after a photothrombotic stroke. Our findings revealed that low- and high-frequency repetitive transcranial magnetic stimulation increased the real-time cerebral blood flow in healthy mice and improved neurobehavioral outcomes after stroke. Furthermore, high-frequency (5-Hz) repetitive transcranial magnetic stimulation revealed stronger functional hyperemia recovery and increased the levels of post-synaptic density 95, neuronal nitric oxide synthase, phosphorylated-endothelial nitric oxide synthase, and vascular endothelial growth factor in the peri-infract cortex compared with low-frequency (1-Hz) repetitive transcranial magnetic stimulation. The magnetic resonance spectroscopy data showed that low- and high-frequency repetitive transcranial magnetic stimulation reduced neuronal injury and maintained excitation/inhibition balance. However, 5-Hz repetitive transcranial magnetic stimulation showed more significant regulation of excitatory and inhibitory neurotransmitters after stroke than 1-Hz repetitive transcranial magnetic stimulation. These results indicated that high-frequency repetitive transcranial magnetic stimulation could more effectively promote neurovascular remodeling after stroke, and specific repetitive transcranial magnetic stimulation frequencies might be used to selectively regulate the neurovascular unit.
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页数：11
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共 45 条
[1]   Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis [J].
Bai, Zhongfei ;
Zhang, Jiaqi ;
Fong, Kenneth N. K. .
JOURNAL OF NEUROENGINEERING AND REHABILITATION, 2022, 19 (01)
[2]   Concurrent TMS-fMRI for causal network perturbation and proof of target engagement [J].
Bergmann, Til Ole ;
Varatheeswaran, Rathiga ;
Hanlon, Colleen A. ;
Madsen, Kristoffer H. ;
Thielscher, Axel ;
Siebner, Hartwig Roman .
NEUROIMAGE, 2021, 237
[3]   Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow [J].
Borsody, Mark K. ;
Yamada, Chisa ;
Bielawski, Dawn ;
Heaton, Tamara ;
Lyeth, Bruce ;
Garcia, Andrea ;
Castro Prado, Fernando ;
Azpiroz, Joaquin ;
Sacristan, Emilio .
BRAIN RESEARCH, 2013, 1528 :58-67
[4]   Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice [J].
Candemir, Esin ;
Fattakhov, Nikolai ;
Leary, Aet O. ;
Slattery, David A. ;
Courtney, Michael J. ;
Reif, Andreas ;
Freudenberg, Florian .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2023, 67 :66-79
[5]   Disturbed cerebral circulation and metabolism matters A preface to the special issue Stroke and Energy Metabolism" [J].
Chen, Yujie .
JOURNAL OF NEUROCHEMISTRY, 2022, 160 (01) :10-12
[6]   Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease [J].
Csiszar, Anna ;
Tarantini, Stefano ;
Fulop, Gabor A. ;
Kiss, Tamas ;
Valcarcel-Ares, M. Noa ;
Galvan, Veronica ;
Ungvari, Zoltan ;
Yabluchanskiy, Andriy .
GEROSCIENCE, 2017, 39 (04) :359-372
[7]   Regional Intervention of Stroke Care to Increase Thrombolytic Therapy for Acute Ischemic Stroke: The Southeast Texas Experience [J].
Damani, Rahul H. ;
Anand, Samyuktha ;
Asgarisabet, Parisa ;
Bissell, Catherine ;
Savitz, Sean ;
Suarez, Jose I. .
STROKE, 2018, 49 (08) :2008-2010
[8]   nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice [J].
Echagarruga, Christina T. ;
Gheres, Kyle W. ;
Norwood, Jordan N. ;
Drew, Patrick J. .
ELIFE, 2020, 9 :1-39
[9]   Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke [J].
El Amki, Mohamad ;
Glueck, Chaim ;
Binder, Nadine ;
Middleham, William ;
Wyss, Matthias T. ;
Weiss, Tobias ;
Meister, Hanna ;
Luft, Andreas ;
Weller, Michael ;
Weber, Bruno ;
Wegener, Susanne .
CELL REPORTS, 2020, 33 (02)
[10]   The Role of Endothelial Ca2+. Signaling in Neurovascular Coupling: A View from the Lumen [J].
Guerra, Germano ;
Lucariello, Angela ;
Perna, Angelica ;
Botta, Laura ;
De Luca, Antonio ;
Moccia, Francesco .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
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