Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

被引：1

作者：

Putnova, Iveta ^{[1
,2
]}

Putnova, Barbora Moldovan ^{[1
,3
]}

Hurnik, Pavel ^{[1
,4
,5
]}

Stembirek, Jan ^{[1
,6
]}

Buchtova, Marcela ^{[1
,7
]}

Koliskova, Petra ^{[1
,7
]}

机构：

[1] Czech Acad Sci, Inst Anim Physiol & Genet, Lab Mol Morphogenesis, Brno, Czech Republic

[2] Univ Vet Sci Brno, Dept Anat Histol & Embryol, Brno, Czech Republic

[3] Univ Vet Sci Brno, Dept Pathol Morphol & Parasitol, Brno, Czech Republic

[4] Univ Hosp Ostrava, Inst Mol & Clin Pathol & Med Genet, Ostrava, Czech Republic

[5] Univ Ostrava, Inst Mol & Clin Pathol & Med Genet, Fac Med, Ostrava, Czech Republic

[6] Univ Hosp Ostrava, Dept Maxillofacial Surg, Ostrava, Czech Republic

[7] Masaryk Univ, Fac Sci, Dept Expt Biol, Brno, Czech Republic

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

head and neck cancer; primary cilium; Hedgehog; Wnt; PDGF; oral squamous cell carcinoma; signalling pathway inhibitors; SMALL-MOLECULE INHIBITORS; GROWTH-FACTOR RECEPTOR; NEURAL STEM-CELLS; PHASE-II TRIAL; SONIC HEDGEHOG; PDGFR-ALPHA; ENDOTHELIAL CILIA; MESENCHYMAL TRANSITIONS; TUMOR MICROENVIRONMENT; TRANSDUCTION PATHWAY;

D O I：

10.3389/fonc.2024.1413255

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.

引用

页数：20

共 301 条

[1] Clinical update on head and neck cancer: molecular biology and ongoing challenges [J].