Diagnostic biomarkers of early anastomotic leakage prediction after colorectal surgery

被引：0
作者：
Todorov, Radoslav S. [1 ]
Yonkov, Atanas S. [1 ]
Shavalov, Zhivko A. [1 ]
Zhivkov, Evgeni E. [1 ]
Hristova, Julieta Z. [2 ,3 ]
Simonova, Lilia B. [1 ]
机构：
[1] Med Univ Sofia, Alexandrovska Univ Hosp, Dept Gen & Operat Surg, Clin Gen & Liver Pancreat Surg,Fac Med, Sofia, Bulgaria
[2] Med Univ Sofia, Dept Clin Lab, Fac Med, Sofia, Bulgaria
[3] Alexandrovska Univ Hosp, Cent Clin Lab Unit, Sofia, Bulgaria
来源：
CHIRURGIA-ITALY | 2024年 / 37卷 / 03期
关键词：
Colorectal surgery; Surgical anastomosis; Anastomotic leak; Biomarkers; Procalcitonin; Interleukin-6; ANTERIOR RESECTION; CANCER SURGERY; DRAIN FLUID; PROCALCITONIN; MORTALITY; INFECTION; CYTOKINES; APPEAL; MARKER;
D O I：
暂无
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
BACKGROUND: Anastomotic leaks still represent a major possibly of a life-threatening complication after colorectal surgery. This study aims to assess biomarkers for early detection of AL following colorectal surgery. METHODS: Clinical, laboratory and statistical study was performed. Blood serum levels of biomarkers - IL-6, TNF-alpha, MMP-9 and PCT - in blood serum and drainage discharge secretion were examined, in 40 patients at second and fifth POD after rectal resection. RESULTS: From the studied proteins IL-6, TNF-alpha, MMP-9 and PCT, in a total of all 40 patients, was found that statically significant results for a potential predictive role for anastomotic leakage have PCT, IL-6 and TNF-alpha. CONCLUSIONS: Studied biomarkers that can identify patients at high risk of developing an AL preoperatively or predict an early AL. By predicting and identifying anastomotic leakage these biomarkers have the potential to significantly change the postoperative outcome in patients with rectal resection and primal anastomosis.
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页码：177 / 182
页数：6
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