The contemporary role of sodium-glucose co-transporter 2 inhibitor (SGLT2i) and angiotensin receptor-neprilysin inhibitor (ARNI) in the management of heart failure: State-of-the-art review

被引：2

作者：

Ezhumalai, Babu ^{[1
]}

Modi, Ranjan ^{[2
]}

Panchanatham, Manokar ^{[3
]}

Kaliyamoorthy, Dhamodaran ^{[4
]}

机构：

[1] Apollo Special Hosp Vanagaram, Dept Cardiol, 64 PH Rd,Vanagaram Ambatturmain Rd,Ayanambakkam, Chennai 600095, Tamil Nadu, India

[2] Indraprastha Apollo Hosp, Dept Cardiol, New Delhi, India

[3] Kauvery Hosp, Dept Cardiol, Chennai, India

[4] Apollo Hosp, Dept Cardiol, Greams Rd, Chennai, India

来源：

INDIAN HEART JOURNAL | 2024年 / 76卷 / 04期

关键词：

Heart failure; SGLT2i; ARNI; Sodium-glucose Co-Transporter 2 inhibitor; Angiotensin receptor neprilysin inhibitor; REDUCED EJECTION FRACTION; CARDIOVASCULAR OUTCOMES; EUROPEAN-SOCIETY; ASSOCIATION; SACUBITRIL/VALSARTAN; METAANALYSIS; EMPAGLIFLOZIN; DAPAGLIFLOZIN; MECHANISMS; CARDIOLOGY;

D O I：

10.1016/j.ihj.2024.07.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Novel therapies for heart failure with reduced ejection fraction (HFrEF) are angiotensin receptor-neprilysin inhibitor (ARNI), sodium-glucose co-transporter 2 inhibitor (SGLT2i), etc. The purpose of this review is to determine the effects of ARNI and SGLT2i in heart failure (HF), compare the impact of SGLT2i with ARNI, and finally evaluate the current data regarding the combination of these two drugs in HF. Various trials on the respective medications have shown some significant reduction in all-cause mortality and cardiovascular (CV) death. The combination of these drugs has shown more CV benefits than monotherapy. There is emerging data about these two drugs in patients with heart failure with preserved ejection fraction (HFpEF). At present, there are less head-to-head comparison trials of these two drugs. This review provides insights on the current evidence, comparative efficacy, and combination therapy of ARNI and SGLT2i in managing HF, focussing on HFrEF and HFpEF.

引用

页码：229 / 239

页数：11

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