Progress in SARS-CoV-2, diagnostic and clinical treatment of COVID-19

被引：5

作者：

Li, Yang ^{[1
,2
]}

Lu, Si-Ming ^{[3
,4
,5
]}

Wang, Jia-Long ^{[1
,2
]}

Yao, Hang-Ping ^{[1
,2
]}

Liang, Li Guo ^{[1
,2
,6
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Natl Clin Res Ctr Infect Dis, Sch Med, Hangzhou, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Lab Med, Hangzhou, Peoples R China

[4] Zhejiang Key Lab Clin Vitro Diagnost Tech, Hangzhou, Peoples R China

[5] Zhejiang Univ, Inst Lab Med, Hangzhou, Peoples R China

[6] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Ctr Clin Lab, Hangzhou, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 12期

关键词：

SARS-CoV-2; COVID-19; Diagnosis; Pharmacological treatment; SARS-CORONAVIRUS; ANTIVIRAL DRUG; SPIKE PROTEIN; ACE2; INHIBITOR; INFECTION; TMPRSS2; CHLOROQUINE; INTERFERON; PROTEASES;

D O I：

10.1016/j.heliyon.2024.e33179

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Corona Virus Disease 2019(COVID-19)is a global pandemic novel coronavirus infection disease caused by Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Although rapid, large-scale testing plays an important role in patient management and slowing the spread of the disease. However, there has been no good and widely used drug treatment for infection and transmission of SARS-CoV-2. Key findings: Therefore, this review updates the body of knowledge on viral structure, infection routes, detection methods, and clinical treatment, with the aim of responding to the large-section caused by SARS-CoV-2. This paper focuses on the structure of SARS-CoV-2 viral protease, RNA polymerase, serine protease and main proteinase-like protease as well as targeted antiviral drugs. Conclusion: In vitro or clinical trials have been carried out to provide deeper thinking for the pathogenesis, clinical diagnosis, vaccine development and treatment of SARS-CoV-2.

引用

页数：20

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