Biological Calorimetry: Old Friend, New Insights

被引：6

作者：

Abian, Olga ^{[1
,2
,3
,4
]}

Vega, Sonia ^{[1
]}

Velazquez-Campoy, Adrian ^{[1
,2
,3
,4
]}

机构：

[1] Univ Zaragoza, Inst Biocomputat & Phys Complex Syst BIFI, Joint Units GBsC CSIC BIFI ICVV CSIC BIFI, Zaragoza 50018, Spain

[2] Univ Zaragoza, Dept Biochem Mol & Cell Biol, Zaragoza 50009, Spain

[3] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain

[4] Ctr Invest Biomed Red Area Temat Enfermedades Hepa, Madrid 28029, Spain

来源：

BIOPHYSICA | 2023年 / 3卷 / 01期

关键词：

biological calorimetry; isothermal titration calorimetry; protein interactions; binding cooperativity; MWC or concerted model; KNF or sequential model; INDUCED FIT; BINDING; NUCLEOPLASMIN; INHIBITION; HEMOGLOBIN; STABILITY; ALLOSTERY; PROTEINS;

D O I：

10.3390/biophysica3010002

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Calorimetry is an old experimental technique (first instrument developed in S. XVIII), but it is broadly used and still provides key information for understanding biological processes at the molecular level, particularly, cooperative phenomena in protein interactions. Here, we review and highlight some key aspects of biological calorimetry. Several biological systems will be described in which calorimetry was instrumental for modeling the behavior of the protein and obtaining further biological insight.

引用

收藏

页码：21 / 34

页数：14

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