Antimicrobial Resistance Patterns of Pathogens Isolated from Patients with Wound Infection at a Teaching Hospital in Vietnam

被引：2

作者：

Van An, Nguyen

Kien, Hoang Trung ^{[1
]}

Hoang, Le Huy ^{[2
]}

Cuong, Nguyen Hung

Quang, Hoang Xuan

Le, Tuan Dinh ^{[3
]}

Thang, Ta Ba ^{[4
]}

Viet, Tien Tran ^{[5
]}

Thuc, Luong Cong ^{[6
]}

Hung, Dinh Viet ^{[7
]}

Viet, Nguyen Hoang ^{[8
]}

Minh, Le Nhat ^{[9
,10
,11
]}

Luong, Vu Huy ^{[1
,2
,12
,13
]}

Nguyen, Vinh Thi Ha ^{[2
,3
,13
,14
]}

Hoa, Pham Quynh ^{[4
,15
]}

Le, Hai Ha Long ^{[5
,6
,16
,17
]}

机构：

[1] Vietnam Mil Med Univ, Mil Hosp 103, Dept Microbiol, Hanoi, Vietnam

[2] Vietnam Mil Med Univ, Dept Immunol, Hanoi, Vietnam

[3] Natl Hyg & Epidemiol, Dept Bacteriol, Hanoi, Vietnam

[4] Vietnam Med Mil Univ, Mil Hosp 103, Dept Rheumatol & Endocrinol, Hanoi, Vietnam

[5] Vietnam Mil Med Univ, Mil Hosp 103, Resp Ctr, Hanoi, Vietnam

[6] Vietnam Med Mil Univ, Mil Hosp 103, Dept Infect Dis, Hanoi, Vietnam

[7] Vietnam Mil Med Univ, Mil Hosp 103, Cardiovasc Ctr, Hanoi, Vietnam

[8] Vietnam Mil Med Univ, Dept Psychiat, Mil Med 103, Hanoi, Vietnam

[9] Hanoi Med Univ, Fac Med Technol, Mol Pathol Dept, Hanoi, Vietnam

[10] Natl Inst Infect Dis, Antimicrobial Resistance Res Ctr, Tokyo, Japan

[11] Vietnam Acad Sci & Technol, Tay Nguyen Inst Sci Res, VAST, Hanoi, Vietnam

[12] Natl Hosp Dermatol & Venereol, Dept Laser & Skincare, Hanoi, Vietnam

[13] Hanoi Med Univ, Dept Dermatol & Venereol, Hanoi, Vietnam

[14] Natl Hosp Dermatol & Venereol, Dept Gen Planning Mycol & Parasitol, Hanoi, Vietnam

[15] Natl Hosp Dermatol & Venereol, Dept Microbiol Mycol & Parasitol, Hanoi, Vietnam

[16] Hanoi Med Univ, Fac Med Technol, Dept Clin Microbiol & Parasitol, Hanoi 100000, Vietnam

[17] Natl Hosp Dermatol & Venereol, Dept Biochem Hematol & Immunol, Hanoi, Vietnam

来源：

INFECTION AND DRUG RESISTANCE | 2024年 / 17卷

基金：

英国科研创新办公室;

关键词：

wound infection; multidrug resistance; antimicrobial resistance; AMR in Vietnam; STAPHYLOCOCCUS-AUREUS; PREVALENCE; ANTIBIOTICS; VANCOMYCIN;

D O I：

10.2147/IDR.S472025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose: At a teaching Hospital in Vietnam, the persistently high incidence of diagnosed wound infection poses ongoing challenges to treatment. This study seeks to explore the causative agents of wound infection and their antimicrobial and multidrug resistance patterns. Methods: A cross-sectional study was conducted at the Department of Microbiology, Military Hospital 103, Vietnam. Data on microorganisms that caused wound infection and their antimicrobial resistance patterns was recorded from hospitalized patients from 2014 to 2021. Using the chi-square test, we analyzed the initial isolation from wound infection specimens collected from individual patients. Results: Over a third (34.9%) of wound infection samples yielded bacterial cultures. Staphylococcus aureus was the most prevalent bacteria, followed by Pseudomonas aeruginosa. . Worryingly high resistance rates were observed for several antibiotics, particularly among Gram-negative bacteria. Ampicillin displayed the highest resistance (91.9%), while colistin and ertapenem remained the most effective. In Gram-positive bacteria, glycopeptides like teicoplanin and vancomycin (0% and 3.3% resistance, respectively) were most effective, but their use was limited. Clindamycin and tetracycline showed decreasing effectiveness. Resistance rates differed between surgical and non-surgical wards, highlighting the complex dynamics of antimicrobial resistance within hospitals. Multidrug resistance (MDR) was substantial, with Gram-negative bacteria exhibiting a 63.6% MDR rate. Acinetobacter baumannii showed the highest MDR rate (88.0%). Conclusion: This study investigated wound infection characteristics, antibiotic resistance patterns of common bacteria, and variations by hospital ward. S. aureus was the most prevalent bacteria, and concerning resistance rates were observed, particularly among Gramnegative bacteria. These findings highlight the prevalence of multidrug resistance in wound infections, emphasizing the importance of infection control measures and judicious antibiotic use.

引用

页码：3463 / 3473

页数：11

共 48 条

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