Mitochondrial quality control dysfunction in osteoarthritis: Mechanisms, therapeutic strategies & future prospects

被引:5
作者
Cheung, Chiyuen [1 ]
Tu, Shaoqin [1 ]
Feng, Yi [1 ]
Wan, Chuiming [1 ]
Ai, Hong [1 ]
Chen, Zheng [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Stomatol, 600 Tianhe Rd, Guangzhou, Guangdong, Peoples R China
[2] 600, Tianhe Rd, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Osteoarthritis; Mitochondrial dysfunction; Mitochondrial quality control; Mitophagy; Oxidative stress; TARGETED ANTIOXIDANT MITOQ; OXIDATIVE STRESS; TRANSCRIPTION-FACTOR; DNA TRANSCRIPTION; KETOGENIC DIET; ACTIVATION; CHONDROCYTES; BIOGENESIS; CARTILAGE; CELLS;
D O I
10.1016/j.archger.2024.105522
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Osteoarthritis (OA) is a prevalent chronic joint disease characterized by articular cartilage degeneration, pain, and disability. Emerging evidence indicates that mitochondrial quality control dysfunction contributes to OA pathogenesis. Mitochondria are essential organelles to generate cellular energy via oxidative phosphorylation and regulate vital processes. Impaired mitochondria can negatively impact cellular metabolism and result in the generation of harmful reactive oxygen species (ROS). Dysfunction in mitochondrial quality control mechanisms has been increasingly linked to OA onset and progression. This review summarizes current knowledge on the role of mitochondrial quality control disruption in OA, highlighting disturbed mitochondrial dynamics, impaired mitochondrial biogenesis, antioxidant defenses and mitophagy. The review also discusses potential therapeutic strategies targeting mitochondrial Quality Control in OA, offering future perspectives on advancing OA therapeutic strategies.
引用
收藏
页数:12
相关论文
共 143 条
  • [1] Bioenergetics and the formation of mitochondrial reactive oxygen species
    Adam-Vizi, Vera
    Chinopoulos, Christos
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (12) : 639 - 645
  • [2] Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis
    Adebayo, Mary
    Singh, Seema
    Singh, Ajay Pratap
    Dasgupta, Santanu
    [J]. FASEB JOURNAL, 2021, 35 (06)
  • [3] Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis
    An, Yanan
    Zhang, Haifeng
    Wang, Chao
    Jiao, Fangtai
    Xu, Hongyue
    Wang, Xuefei
    Luan, Wenjing
    Ma, Fangxue
    Ni, Lihui
    Tang, Xudong
    Liu, Mingyuan
    Guo, Weiying
    Yu, Lu
    [J]. FASEB JOURNAL, 2019, 33 (11) : 12515 - 12527
  • [4] Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
    Ansari, M. Y.
    Khan, N. M.
    Ahmad, I.
    Haqqi, T. M.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2018, 26 (08) : 1087 - 1097
  • [5] The pathways of mitophagy for quality control and clearance of mitochondria
    Ashrafi, G.
    Schwarz, T. L.
    [J]. CELL DEATH AND DIFFERENTIATION, 2013, 20 (01) : 31 - 42
  • [6] Mitochondrial protein quality control during biogenesis and aging
    Baker, Brooke M.
    Haynes, Cole M.
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2011, 36 (05) : 254 - 261
  • [7] Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
    Bao, Jiapeng
    Chen, Zhonggai
    Xu, Langhai
    Wu, Lidong
    Xiong, Yan
    [J]. AGING-US, 2020, 12 (06): : 5152 - 5167
  • [8] Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging
    Ben-Meir, Assaf
    Burstein, Eliezer
    Borrego-Alvarez, Aluet
    Chong, Jasmine
    Wong, Ellen
    Yavorska, Tetyana
    Naranian, Taline
    Chi, Maggie
    Wang, Ying
    Bentov, Yaakov
    Alexis, Jennifer
    Meriano, James
    Sung, Hoon-Ki
    Gasser, David L.
    Moley, Kelle H.
    Hekimi, Siegfried
    Casper, Robert F.
    Jurisicova, Andrea
    [J]. AGING CELL, 2015, 14 (05) : 887 - 895
  • [9] Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
    Bertholet, A. M.
    Delerue, T.
    Millet, A. M.
    Moulis, M. F.
    David, C.
    Daloyau, M.
    Arnaune-Pelloquin, L.
    Davezac, N.
    Mils, V.
    Miguel, M. C.
    Rojo, M.
    Belenguer, P.
    [J]. NEUROBIOLOGY OF DISEASE, 2016, 90 : 3 - 19
  • [10] Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis
    Blanco, F. J.
    Fernandez-Moreno, M.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2020, 28 (08) : 1003 - 1006