Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Background Long COVID is an emerging global public health issue. Socially vulnerable communities in low- and- middle-income countries were severely impacted by the pandemic and are underrepresented in research. This prospective study aimed to determine the prevalence of long COVID, its impact on health, and associated risk factors in one such community in Rio de Janeiro, Brazil. Methods A total of 710 individuals aged 18 and older, with confirmed fi rmed SARS-CoV-2 infection at least three months prior, were enrolled between November 25, 2021, and May 5, 2022. Participants were assessed via telephone or in person using a standardized questionnaire to evaluate their perception of recovery, symptoms, quality of life, and functional status. Findings Twenty percent of participants did not feel fully recovered, 22% experienced new or persistent symptoms, 26% had worsened functional status, 18% had increased dyspnoea, and 32% reported a worse quality of life. Persistent symptoms included headache, cough, fatigue, muscle pain, and shortness of breath. Dyspnoea during the acute phase was the strongest independent predictor of worsening outcomes. Females and individuals with comorbidities were more likely to report worse recovery, functioning, dyspnoea, and quality of life. Interpretation Our fi ndings reveal a high burden of severe and persistent physical and mental health sequelae in a socially vulnerable community following COVID-19. Funding UK Foreign, Commonwealth and Development Office fi ce and Wellcome Trust Grant (222048/Z/20/Z), Funda & ccedil;& atilde;o Oswaldo Cruz (FIOCRUZ), Funda & ccedil;& atilde;o de Amparo & agrave; Pesquisa do Estado do Rio de Janeiro (FAPERJ), and the Centers for Disease Control and Prevention (CDC).