Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water

被引：2

作者：

Lu, Qinli ^{[1
,2
]}

Wang, Xianming ^{[1
,2
]}

Wen, Wanliu ^{[1
,2
]}

Fan, Ruifeng ^{[1
,2
]}

Zhu, Binfeng ^{[1
,2
]}

Zhou, Bingjie ^{[1
,2
]}

Chen, Jingchao ^{[1
,2
]}

Fan, Baomin ^{[1
,2
,3
,4
,5
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Peoples R China

[2] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Peoples R China

[3] Yunnan Minzu Univ, Dept Sch Chem & Environm, Kunming 650500, Peoples R China

[4] Kunming Med Univ, Sch Pharmaceut Sci, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China

[5] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2024年 / 5卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Asymmetric reduction; Unsaturated nitriles; Water; Propionitrile; Iridium; DIBAL-H; TRANSFER HYDROGENATION; ALKENES; AMINES; ACID; LIGANDS; ESTERS;

D O I：

10.1016/j.gresc.2023.07.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals, and the nitrile groups are versatile synthetic intermediates to other functionalized compounds. Herein, the asymmetric reduction of alpha, beta-unsaturated nitriles with water as a hydrogen source is reported. The reaction is catalyzed by the complex of [Ir(COD)Cl](2) and (R-a, S)-Ph-Bn-SiPhox, and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.

引用

收藏

页码：175 / 179

页数：5

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