SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53

被引：17

作者：

Chen, Fengjuan ^{[1
,2
]}

Zhang, Ka ^{[3
]}

Huang, Yilin ^{[4
]}

Luo, Fang ^{[1
]}

Hu, Kunpeng ^{[5
]}

Cai, Qingxian ^{[1
]}

机构：

[1] Third Peoples Hosp Shenzhen, Dept Hepatol, 29 Bulan Rd, Shenzhen 518112, Peoples R China

[2] Guangzhou Eighth Peoples Hosp, Dept Hepatol, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Dept Infect Dis, Affiliated Hosp 3, Guangzhou, Peoples R China

[4] Guangdong Prov Peoples Hosp, Dept Rehabil, Guangzhou, Peoples R China

[5] Sun Yat Sen Univ, Dept Gen Surg, Affiliated Hosp 3, Guangzhou 510000, Peoples R China

来源：

FEBS OPEN BIO | 2020年 / 10卷 / 07期

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; metastasis; p53; proliferation; SPC25; WGCNA; LIVER-DISEASE; CANCER; LOOP;

D O I：

10.1002/2211-5463.12872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor-promoting factor in HCC and may act via the p53 pathway.

引用

页码：1261 / 1275

页数：15

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