Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity

被引:0
作者
Dinep-Schneider, Olivia [1 ]
Appiah, Eastilan [2 ]
Dapper, Amy [1 ]
Patterson, Sarah [2 ]
Vermulst, Marc [3 ]
Gout, Jean-Francois [1 ]
机构
[1] Mississippi State Univ, Dept Biol, Starkville, MS 39759 USA
[2] Mississippi State Univ, Dept Comp Sci & Engn, Computat Biol, Starkville, MS USA
[3] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
关键词
NON-HODGKIN-LYMPHOMA; DNA-DAMAGE; MUTAGENESIS; EXPOSURE; CARCINOGENICITY; MECHANISMS; CYTOSINES; TOXICITY;
D O I
10.1016/j.envpol.2024.124203
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Glyphosate-based weed killers such as Roundup have been implicated in detrimental effects on single- and multicellular eukaryotic model organism health and longevity. However, the mode(s) of action for these effects are currently unknown. In this study, we investigate the impact of exposure to Roundup on two model organisms: Saccharomyces cerevisiae and Caenorhabditis elegans and test the hypothesis that exposure to Roundup decreases transcription fidelity. Population growth assays and motility assays were performed in order to determine the phenotypic effects of Roundup exposure. We also used Rolling-Circle Amplification RNA sequencing to quantify the impact of exposure to Roundup on transcription fidelity in these two model organisms. Our results show that exposure to the glyphosatebased herbicide Roundup increases mortality, reduces reproduction, and increases transcription error rates in C. elegans and S. cerevisiae . We suggest that these effects may be due in part to the involvement of inflammation and oxidative stress, conditions which may also contribute to increases in transcription error rates.
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页数:11
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