The roles of tertiary lymphoid structures in genitourinary cancers: molecular mechanisms, therapeutic strategies, and clinical applications

被引:0
作者
Yang, Jie [1 ]
Xiong, Xingyu [1 ]
Zheng, Weitao [1 ]
Xu, Hang [1 ]
Liao, Xinyang [1 ]
Wei, Qiang [1 ]
Yang, Lu [1 ]
机构
[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
antitumor immunity; genitourinary cancer; immune checkpoint blockade; tertiary lymphoid structures; tumor immune microenvironment; RESISTANT PROSTATE-CANCER; RENAL-CELL CARCINOMA; PHASE-III TRIAL; B-CELLS; T-CELLS; UROTHELIAL CARCINOMA; PROGNOSTIC RELEVANCE; CHRONIC INFLAMMATION; IMMUNE CONTEXTURE; PLASMA-CELLS;
D O I
10.1097/JS9.0000000000001939
中图分类号
R61 [外科手术学];
学科分类号
摘要
The presence of tertiary lymphoid structures (TLSs) associated with distinct treatment efficacy and clinical prognosis has been identified in various cancer types. However, the mechanistic roles and clinical implications of TLSs in genitourinary (GU) cancers remain incompletely explored. Despite their potential role as predictive markers described in numerous studies, it is essential to comprehensively evaluate the characteristics of TLSs, including drivers of formation, structural foundation, cellular compositions, maturation stages, molecular features, and specific functionality to maximize their positive impacts on tumor-specific immunity. The unique contributions of these structures to cancer progression and biology have fueled interest in these structures as mediators of antitumor immunity. Emerging data are trying to explore the effects of therapeutic interventions targeting TLSs. Therefore, a better understanding of the molecular and phenotypic heterogeneity of TLSs may facilitate the development of TLSs-targeting therapeutic strategies to obtain optimal clinical benefits for GU cancers in the setting of immunotherapy. In this review, the authors focus on the phenotypic and functional heterogeneity of TLSs in cancer progression, current therapeutic interventions targeting TLSs and the clinical implications and therapeutic potential of TLSs in GU cancers.
引用
收藏
页码:5007 / 5021
页数:15
相关论文
共 164 条
  • [91] Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer
    Masuda, Tsukasa
    Tanaka, Nobuyuki
    Takamatsu, Kimiharu
    Hakozaki, Kyohei
    Takahashi, Ryohei
    Anno, Tadatsugu
    Kufukihara, Ryohei
    Shojo, Kazunori
    Mikami, Shuji
    Shinojima, Toshiaki
    Kakimi, Kazuhiro
    Tsunoda, Tatsuhiko
    Aimono, Eriko
    Nishihara, Hiroshi
    Mizuno, Ryuichi
    Oya, Mototsugu
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (03)
  • [92] Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors
    Matsubara, Shiro
    Seki, Morinobu
    Suzuki, Shigeaki
    Komori, Takashi
    Takamori, Mikio
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01)
  • [93] Organogenesis of lymphoid tissues
    Mebius, RE
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (04) : 292 - 303
  • [94] Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer
    Meylan, Maxime
    Petitprez, Florent
    Becht, Etienne
    Bougouein, Antoine
    Pupier, Guilhem
    Calvez, Anne
    Giglioli, Ilenia
    Verkarre, Virginie
    Lacroix, Guillaume
    Verneau, Johanna
    Sun, Chen-Ming
    Laurent-Puig, Pierre
    Vano, Yann-Alexandre
    Elaidi, Reza
    Mejean, Arnaud
    Sanchez-Salas, Rafael
    Barret, Eric
    Cathelineau, Xavier
    Oudard, Stephane
    Reynaud, Claude-Agnes
    de Reynies, Aurelien
    Sautes-Fridman, Catherine
    Fridman, Wolf Herman
    [J]. IMMUNITY, 2022, 55 (03) : 527 - +
  • [95] Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
    Miller, Brian C.
    Sen, Debattama R.
    Al Abosy, Rose
    Bi, Kevin
    Virkud, Yamini V.
    LaFleur, Martin W.
    Yates, Kathleen B.
    Lako, Ana
    Felt, Kristen
    Naik, Girish S.
    Manos, Michael
    Gjini, Evisa
    Kuchroo, Juhi R.
    Ishizuka, Jeffrey J.
    Collier, Jenna L.
    Griffin, Gabriel K.
    Maleri, Seth
    Comstock, Dawn E.
    Weiss, Sarah A.
    Brown, Flavian D.
    Panda, Arpit
    Zimmer, Margaret D.
    Manguso, Robert T.
    Hodi, F. Stephen
    Rodig, Scott J.
    Sharpe, Arlene H.
    Haining, W. Nicholas
    [J]. NATURE IMMUNOLOGY, 2019, 20 (03) : 326 - +
  • [96] Hallmarks of response, resistance, and toxicity to immune checkpoint blockade
    Morad, Golnaz
    Helmink, Beth A.
    Sharma, Padmanee
    Wargo, Jennifer A.
    [J]. CELL, 2021, 184 (21) : 5309 - 5337
  • [97] APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures
    Morcrette, Guillaume
    Hirsch, Theo Z.
    Badour, Elise
    Pilet, Jill
    Caruso, Stefano
    Calderaro, Julien
    Martin, Yoann
    Imbeaud, Sandrine
    Letouze, Eric
    Rebouissou, Sandra
    Branchereau, Sophie
    Taque, Sophie
    Chardot, Christophe
    Guettier, Catherine
    Scoazec, Jean-Yves
    Fabre, Monique
    Brugieres, Laurence
    Zucman-Rossi, Jessica
    [J]. ONCOIMMUNOLOGY, 2019, 8 (06):
  • [98] Lymphotoxin-alpha contributes to lymphangiogenesis
    Mounzer, Rawad H.
    Svendsen, Oyvind S.
    Baluk, Peter
    Bergman, Cheryl M.
    Padera, Timothy P.
    Wiig, Helge
    Jain, Rakesh K.
    McDonald, Donald M.
    Ruddle, Nancy H.
    [J]. BLOOD, 2010, 116 (12) : 2173 - 2182
  • [99] Nakano O, 2001, CANCER RES, V61, P5132
  • [100] Emergence and Evolution of Secondary Lymphoid Organs
    Neely, Harold R.
    Flajnik, Martin F.
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32, 2016, 32 : 693 - 711