Mucosal associated invariant T cells: Powerhouses of the lung

被引：1
作者：
Lopez-Rodriguez, J. C. [1 ,2 ,3 ]
Barral, P. [1 ,2 ]
机构：
[1] Kings Coll London, Ctr Inflammat Biol & Canc Immunol, Peter Gorer Dept Immunobiol, London, England
[2] Francis Crick Inst, London, England
[3] Univ San Pablo CEU, Fac Med, Inst Med Mol Aplicada Nemesio Diez, Madrid, Spain
来源：
IMMUNOLOGY LETTERS | 2024年 / 269卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
MAIT cells; Lung immunity; MR1; Infection; Inflammation; HUMAN MAIT CELLS; ACTIVATION; TCR; INNATE;
D O I：
10.1016/j.imlet.2024.106910
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs' immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue homeostasis and to the early initiation of immune responses. Amongst tissue- resident lymphocytes, Mucosal Associated Invariant T (MAIT) cells are present in human and murine lungs and emerging evidence supports their contribution to immune responses during infections, chronic inflammatory disorders and cancer. This review explores the mechanisms underpinning MAIT cell functions in the airways, their impact on lung immunity and the potential for targeting pulmonary MAIT cells in a therapeutic context.
引用
收藏
页数：8
相关论文
共 93 条
  • [1] Mucosal-associated invariant T cells: new players in CF lung disease?
    Anil, Nidhi
    [J]. INFLAMMATION RESEARCH, 2019, 68 (08) : 633 - 638
  • [2] A conserved transcriptional program for MAIT cells across mammalian evolution
    Bugaut, Helene
    El Morr, Yara
    Mestdagh, Martin
    Darbois, Aurelie
    Paiva, Rafael A.
    Salou, Marion
    Perrin, Laetitia
    Fuerstenheim, Mariela
    du Halgouet, Anastasia
    Bilonda-Mutala, Linda
    Le Gac, Anne-Laure
    Arnaud, Manon
    El Marjou, Ahmed
    Guerin, Coralie
    Chaiyasitdhi, Atitheb
    Piquet, Julie
    Smadja, David M.
    Cieslak, Agata
    Ryffel, Bernhard
    Maciulyte, Valdone
    Turner, James M. A.
    Bernardeau, Karine
    Montagutelli, Xavier
    Lantz, Olivier
    Legoux, Francois
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 221 (02)
  • [3] Transcriptomes and metabolism define mouse and human MAIT cell populations
    Chandra, Shilpi
    Ascui, Gabriel
    Riffelmacher, Thomas
    Chawla, Ashu
    Ramirez-Suastegui, Ciro
    Castelan, Viankail C.
    Seumois, Gregory
    Simon, Hayley
    Murray, Mallory P.
    Seo, Goo-Young
    Premlal, Ashmitaa L. R.
    Schmiedel, Benjamin
    Verstichel, Greet
    Li, Yingcong
    Lin, Chia-Hao
    Greenbaum, Jason
    Lamberti, John
    Murthy, Raghav
    Nigro, John
    Cheroutre, Hilde
    Ottensmeier, Christian H.
    Hedrick, Stephen M.
    Lu, Li-Fan
    Vijayanand, Pandurangan
    Kronenberg, Mitchell
    [J]. SCIENCE IMMUNOLOGY, 2023, 8 (89)
  • [4] Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment
    Chandra, Shilpi
    Wingender, Gerhard
    Greenbaum, Jason A.
    Khurana, Archana
    Gholami, Amin M.
    Ganesan, Anusha-Preethi
    Rosenbach, Michael
    Jaffee, Katy
    Gern, James E.
    Wood, Robert
    O'Connor, George
    Sandel, Megan
    Kattan, Meyer
    Bacharier, Leonard
    Togias, Alkis
    Horner, Anthony A.
    Kronenberg, Mitchell
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (06) : 1995 - 2003
  • [5] Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
    Chen, Z.
    Wang, H.
    D'Souza, C.
    Sun, S.
    Kostenko, L.
    Eckle, S. B. G.
    Meehan, B. S.
    Jackson, D. C.
    Strugnell, R. A.
    Cao, H.
    Wang, N.
    Fairlie, D. P.
    Liu, L.
    Godfrey, D. I.
    Rossjohn, J.
    McCluskey, J.
    Corbett, A. J.
    [J]. MUCOSAL IMMUNOLOGY, 2017, 10 (01) : 58 - 68
  • [6] Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection
    Chua, Wei-Jen
    Truscott, Steven M.
    Eickhoff, Christopher S.
    Blazevic, Azra
    Hoft, Daniel F.
    Hansen, Ted H.
    [J]. INFECTION AND IMMUNITY, 2012, 80 (09) : 3256 - 3267
  • [7] T-cell activation by transitory neo-antigens derived from distinct microbial pathways
    Corbett, Alexandra J.
    Eckle, Sidonia B. G.
    Birkinshaw, Richard W.
    Liu, Ligong
    Patel, Onisha
    Mahony, Jennifer
    Chen, Zhenjun
    Reantragoon, Rangsima
    Meehan, Bronwyn
    Cao, Hanwei
    Williamson, Nicholas A.
    Strugnell, Richard A.
    Van Sinderen, Douwe
    Mak, Jeffrey Y. W.
    Fairlie, David P.
    Kjer-Nielsen, Lars
    Rossjohn, Jamie
    McCluskey, James
    [J]. NATURE, 2014, 509 (7500) : 361 - +
  • [8] Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation
    Cui, Yue
    Franciszkiewicz, Katarzyna
    Mburu, Yvonne K.
    Mondot, Stanislas
    Le Bourhis, Lionel
    Premel, Virginie
    Martin, Emmanuel
    Kachaner, Alexandra
    Duban, Livine
    Ingersoll, Molly A.
    Rabot, Sylvie
    Jaubert, Jean
    De Villartay, Jean-Pierre
    Soudais, Claire
    Lantz, Olivier
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (11) : 4171 - 4185
  • [9] Dias J, 2017, METHODS MOL BIOL, V1514, P241, DOI 10.1007/978-1-4939-6548-9_17
  • [10] Edmans M.D., 2024, J. Biol. Chem., V300
12345678910