Single-Molecule Electronic Biosensors: Principles and Applications

被引:3
作者
Chang, Xinyue [1 ]
Huo, Yani [1 ]
Zhao, Cong [1 ]
Sun, Wanqi [1 ]
Song, Ziqi [1 ]
Qi, Ziyuan [1 ]
Wang, Jinying [1 ,2 ]
Jia, Chuancheng [1 ]
Guo, Xuefeng [1 ,3 ]
机构
[1] Nankai Univ, Inst Modern Opt, Coll Elect Informat & Opt Engn, Ctr Single Mol Sci, 38 Tongyan Rd, Tianjin 300350, Peoples R China
[2] Purdue Univ, Network Computat Nanotechnol, W Lafayette, IN 47907 USA
[3] Peking Univ, Coll Chem & Mol Engn, Natl Biomed Imaging Ctr, Beijing Natl Lab Mol Sci, 292 Chengfu Rd, Beijing 100871, Peoples R China
来源
ADVANCED SENSOR RESEARCH | 2023年 / 2卷 / 05期
关键词
biosensors; field effect; fluorescence; low dimensional materials; single molecule; FIELD-EFFECT-TRANSISTOR; SILICON NANOWIRES; DNA; GRAPHENE; DYNAMICS; CONDUCTANCE; LIMITATIONS; MECHANISMS; RESOLUTION; PROTEINS;
D O I
10.1002/adsr.202200084
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Single-biomolecule electronic sensing techniques are of great importance in many fields, from medical diagnosis to disease surveillance. As the physiological changes of single biomolecules can be converted into measurable electrical signals, single-molecule electronic biosensors can realize real-time, highly sensitive, and high-bandwidth detection of individual intra- or inter-molecular interactions. These powerful single-molecule sensing devices have demonstrated key advantages in precisely providing rare and detailed intermediate information along reaction pathways and revealing unique properties hidden in ensemble measurements. This review summarizes significant advances in single-molecule electronic biosensors, emphasizing biomolecule recognition, interaction, and reaction dynamics at the single-molecule level. Sensor configurations, sensing mechanisms, and representative applications are also discussed. Furthermore, a perspective on the use of photoelectric integrated systems for synchronous sensing of the electrical and optical signals of single biomolecules is provided. The attraction of single-molecule electronic biosensors to biomedicine and life science is manifold. The strategies for constructing single-molecule sensing platforms, including silicon nanowires, carbon nanotubes, 2D nanomaterials, and molecular bridges, are reviewed. The working principles, device architectures, and practical applications are summarized. A perspective of photoelectric integrated systems for improving the detection performance of single biomolecules is also provided. image
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页数:24
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