Brain region changes following a spinal cord injury

被引:2
|
作者
Wu, Zhiwu [1 ]
Feng, Kaiming [1 ]
Huang, Jinqing [1 ]
Ye, Xinyun [1 ]
Yang, Ruijin [1 ]
Huang, Qianliang [1 ]
Jiang, Qiuhua [1 ]
机构
[1] Southern Med Univ, Ganzhou Peoples Hosp, Ganzhou Hosp, Dept Neurosurg,Nanfang Hosp, 16th Mei Guan Ave, Ganzhou 341000, Peoples R China
关键词
Brain region changes; Brain function remodeling; Brain-related complications; Spinal cord injury; Transcranial therapy; CHRONIC NEUROPATHIC PAIN; IMPROVES MOTOR FUNCTION; FUNCTIONAL CONNECTIVITY; COGNITIVE IMPAIRMENT; MAGNETIC STIMULATION; PREFRONTAL CORTEX; RAT-BRAIN; EXPRESSION; SENSORIMOTOR; THALAMUS;
D O I
10.1016/j.neuint.2024.105696
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Brain-related complications are common in clinical practice after spinal cord injury (SCI); however, the molecular mechanisms of these complications are still unclear. Here, we reviewed the changes in the brain regions caused by SCI from three perspectives: imaging, molecular analysis, and electrophysiology. Imaging studies revealed abnormal functional connectivity, gray matter volume atrophy, and metabolic abnormalities in brain regions after SCI, leading to changes in the structure and function of brain regions. At the molecular level, chemokines, inflammatory factors, and damage-associated molecular patterns produced in the injured area were retrogradely transmitted through the corticospinal tract, cerebrospinal fluid, or blood circulation to the specific brain area to cause pathologic changes. Electrophysiologic recordings also suggested abnormal changes in brain electrical activity after SCI. Transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation alleviated pain and improved motor function in patients with SCI; therefore, transcranial therapy may be a new strategy for the treatment of patients with SCI.
引用
收藏
页数:13
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