Ashwagandha's Multifaceted Effects on Human Health: Impact on Vascular Endothelium, Inflammation, Lipid Metabolism, and Cardiovascular Outcomes-A Review

被引：1

作者：

Wicinski, Michal ^{[1
]}

Fajkiel-Madajczyk, Anna ^{[1
]}

Kurant, Zuzanna ^{[1
]}

Liss, Sara ^{[1
]}

Szyperski, Pawel ^{[1
]}

Szambelan, Monika ^{[1
]}

Gromadzki, Bartlomiej ^{[1
]}

Rupniak, Iga ^{[2
]}

Slupski, Maciej ^{[3
]}

Sadowska-Krawczenko, Iwona ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ, Fac Med, Dept Pharmacol & Therapeut, Coll Med Bydgoszcz, M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Dept Neonatol, Ludw Rydygier Coll Med Bydgoszcz, Ul Ujejskiego 75, PL-85168 Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ, Fac Med, Dept Hepatobiliary & Gen Surg, Coll Med Bydgoszcz, M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

来源：

NUTRIENTS | 2024年 / 16卷 / 15期

关键词：

ashwagandha; lipid metabolism; inflammation; vascular endothelium; cardiovascular outcomes; UBIQUITIN-PROTEASOME PATHWAY; WITHANIA-SOMNIFERA; NITRIC-OXIDE; SUPPLEMENTATION; HYPERTENSION; MECHANISMS; WITHAFERIN; EXTRACTS; PROFILE; STRESS;

D O I：

10.3390/nu16152481

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Withania somnifera, commonly known as Ashwagandha, has been popular for many years. Numerous studies have shown that the extract of this plant, due to its wealth of active substances, can induce anti-inflammatory, neuroprotective, immunomodulatory, hepatoprotective, cardioprotective, anti-diabetic, adaptogenic, anti-arthritic, anti-stress, and antimicrobial effects. This review examines the impact of Ashwagandha extract on the vascular endothelium, inflammation, lipid metabolism, and cardiovascular outcomes. Studies have shown that Ashwagandha extracts exhibit an anti-angiogenic effect by inhibiting vascular endothelial growth factor (VEGF)-induced capillary sprouting and formation by lowering the mean density of microvessels. Furthermore, the results of numerous studies highlight the anti-inflammatory role of Ashwagandha extract, as the action of this plant causes a decrease in the expression of pro-inflammatory cytokines. Interestingly, withanolides, present in Ashwagandha root, have shown the ability to inhibit the differentiation of preadipocytes into adipocytes. Research results have also proved that W. somnifera demonstrates cardioprotective effects due to its antioxidant properties and reduces ischemia/reperfusion-induced apoptosis. It seems that this plant can be successfully used as a potential treatment for several conditions, mainly those with increased inflammation. More research is needed to elucidate the exact mechanisms by which the substances contained in W. somnifera extracts can act in the human body.

引用

页数：19