High Concordance Between Nonalcoholic Fatty Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease in the TARGET-NASH Real-World Cohort

被引：12

作者：

Barritt IV, A. Sidney ^{[1
]}

Yu, Feng ^{[2
]}

Mospan, Andrea R. ^{[2
]}

Newsome, Phillip N. ^{[3
]}

Roden, Michael ^{[4
]}

Morris, Heather L. ^{[2
]}

Loomba, Rohit ^{[5
]}

Neuschwander-Tetri, Brent A. ^{[6
]}

机构：

[1] Univ N Carolina, UNC Liver Ctr, Chapel Hill, NC 27599 USA

[2] Target RWE, Durham, NC USA

[3] Univ Birmingham, Birmingham, England

[4] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[5] Univ Calif San Diego, Dept Med, Div Gastroenterol, San Diego, CA USA

[6] St Louis Univ, Div Gastroenterol & Hepatol, St Louis, MO USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2024年 / 119卷 / 08期

关键词：

NAFLD; NASH; MASLD; MASH; steatosis; nomenclature;

D O I：

10.14309/ajg.0000000000002796

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:This study investigates the applicability of the new metabolic dysfunction-associated steatotic liver disease (MASLD) nomenclature to the real-world TARGET-NASH US adult cohort.METHODS:The new MASLD/metabolic steatohepatitis nomenclature was applied to patients enrolled with pragmatic diagnoses of nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH), and NASH cirrhosis and concordance were determined between the definitions.RESULTS:Approximately 99% of TARGET-NASH participants met the new MASLD diagnostic criteria. Approximately 1,484/1,541 (96.3%, kappa 0.974) nonalcoholic fatty liver patients (metabolic dysfunction-associated steatotic liver), 2,195/2,201 (99.7%, kappa 0.998) NASH patients (metabolic steatohepatitis), and 1,999/2,003 (99.8%, kappa 0.999) NASH cirrhosis patients met the new criteria.DISCUSSION:The new MASLD nomenclature is highly concordant with the previous TARGET-NASH pragmatic definitions.

引用

页码：1624 / 1627

页数：4

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