ROLES OF HUMAN CYTOCHROME P450 1A2, 2C9, AND 3A4/5 ENZYMES IN DRUG OXIDATIONS MEDIATED BY METABOLICALLY INACTIVATED HUMAN HEPATOCYTES IN PREVIOUSLY TRANSPLANTED CHIMERIC MICE

被引:0
|
作者
Yamazaki, Hiroshi [1 ]
Uehara, Shotaro [2 ]
Shimizu, Makiko [1 ]
Suemizu, Hiroshi [2 ]
机构
[1] Showa Pharmaceut Univ, Machida, Tokyo, Japan
[2] CIEA, Kawasaki, Japan
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P25
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone
    Shou, MG
    Korzekwa, KR
    Brooks, EN
    Krausz, KW
    Gonzalez, FJ
    Gelboin, HV
    CARCINOGENESIS, 1997, 18 (01) : 207 - 214
  • [22] Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli
    Vail, RB
    Homann, MJ
    Hanna, I
    Zaks, A
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2005, 32 (02) : 67 - 74
  • [23] Metabolic interaction of isoniazid and rifampicin on cytochrome P450 1A2 and 3A4 by using replatable cryopreserved human primary hepatocytes
    Cai, Yingyun
    Liu, Zhengwei
    Fang, Sishi
    Liu, Zhengwei
    Hu, Zhuohan
    Cai, Yingyun
    Hu, Zhuohan
    DRUG METABOLISM REVIEWS, 2006, 38 : 97 - 97
  • [24] Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes
    McBride, Grace M.
    Soo, Jia Yin
    Varcoe, Tamara
    Morrison, Janna L.
    Wiese, Michael D.
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020, 106
  • [25] Induction of cytochrome P450 1A1/2 and 3A4 activities in cyropreserved human hepatocytes
    Garcia, M
    Rager, J
    Wang, Q
    Hidalgo, IJ
    Owen, A
    Li, JB
    DRUG METABOLISM REVIEWS, 2003, 35 : 73 - 73
  • [26] Inhibitory Effects of Eight Green Tea Catechins on Cytochrome P450 1A2, 2C9, 2D6, and 3A4 Activities
    Satoh, Takashi
    Fujisawa, Haruka
    Nakamura, Ami
    Takahashi, Natsuko
    Watanabe, Kazuhiro
    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2016, 19 (02): : 188 - 197
  • [27] Predicting Drug Metabolism by Cytochrome P450 2C9: Comparison with the 2D6 and 3A4 Isoforms
    Rydberg, Patrik
    Olsen, Lars
    CHEMMEDCHEM, 2012, 7 (07) : 1202 - 1209
  • [28] Polymorphisms of human cytochrome P450 2C9 and the functional relevance
    Zhou, Shu-Feng
    Zhou, Zhi-Wei
    Huang, Min
    TOXICOLOGY, 2010, 278 (02) : 165 - 188
  • [29] Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes
    Yamazaki, H
    Shaw, PM
    Guengerich, FP
    Shimada, T
    CHEMICAL RESEARCH IN TOXICOLOGY, 1998, 11 (06) : 659 - 665
  • [30] Regulation of cytochrome P450 (CYP) 2C9 expression in human hepatocytes by various xenobiotics.
    Shord, SS
    Gilbert, D
    Hamilton, G
    Faucette, S
    Clarke, M
    Pescatore, S
    Jolley, S
    Lindley, C
    LeCluyse, EL
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2002, 71 (02) : P29 - P29