Biomedical SERS - the current state and future trends

被引：28

作者：

Cialla-May, Dana ^{[1
,2
,3
,4
,5
,6
]}

Bonifacio, Alois ^{[7
]}

Bocklitz, Thomas ^{[1
,2
,3
,4
,5
,6
,8
]}

Markin, Alexey ^{[9
]}

Markina, Natalia ^{[9
]}

Fornasaro, Stefano ^{[10
]}

Dwivedi, Aradhana ^{[1
,2
,3
,4
,5
,6
]}

Dib, Tony ^{[1
,2
,3
,4
,5
,6
]}

Farnesi, Edoardo ^{[4
,5
,6
]}

Liu, Chen ^{[1
,2
,3
,4
,5
,6
]}

Ghosh, Arna ^{[1
,2
,3
,4
,5
,6
]}

Popp, Juergen ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Leibniz Inst Photon Technol, Albert Einstein Str 9, D-07745 Jena, Germany

[2] Leibniz Hlth Technol, Albert Einstein Str 9, D-07745 Jena, Germany

[3] Leibniz Ctr Photon Infect Res LPI, Albert Einstein Str 9, D-07745 Jena, Germany

[4] Friedrich Schiller Univ Jena, Inst Phys Chem IPC, Helmholtzweg 4, D-07743 Jena, Germany

[5] Friedrich Schiller Univ Jena, Abbe Ctr Photon ACP, Helmholtzweg 4, D-07743 Jena, Germany

[6] Leibniz Ctr Photon Ininfect Res LPI, Helmholtzweg 4, D-07743 Jena, Germany

[7] Univ Trieste, Dept Engn & Architecture, Via Alfonso Valerio 6, I-34127 Trieste, TS, Italy

[8] Univ Bayreuth, Fac Math Phys & Comp Sci, Nurnberger Str 38, D-95440 Bayreuth, Germany

[9] Saratov NG Chernyshevskii State Univ, Inst Chem, Astrakhanskaya St 83, Saratov 410012, Russia

[10] Univ Trieste, Dept Chem & Pharmaceut Sci, Via Licio Giorgieri 1, I-34127 Trieste, TS, Italy

来源：

CHEMICAL SOCIETY REVIEWS | 2024年 / 53卷 / 18期

关键词：

ENHANCED RAMAN-SPECTROSCOPY; AG; NANOPARTICLES; DIAGNOSIS; AU; IDENTIFICATION; BACTERIA; SENSOR;

D O I：

10.1039/d4cs00090k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surface enhanced Raman spectroscopy (SERS) is meeting the requirements in biomedical science being a highly sensitive and specific analytical tool. By employing portable Raman systems in combination with customized sample pre-treatment, point-of-care-testing (POCT) becomes feasible. Powerful SERS-active sensing surfaces with high stability and modification layers if required are available for testing and application in complex biological matrices such as body fluids, cells or tissues. This review summarizes the current state in sample collection and pretreatment in SERS detection protocols, SERS detection schemes, i.e. direct and indirect SERS as well as targeted and non-targeted SERS, and SERS-active sensing surfaces. Moreover, the recent developments and advances of SERS in biomedical application scenarios, such as infectious diseases, cancer diagnostics and therapeutic drug monitoring is given, which enables the readers to identify the sample collection and preparation protocols, SERS substrates and detection strategies that are best-suited for their specific applications in biomedicine. Surface enhanced Raman spectroscopy (SERS) is meeting the requirements in biomedical science being a highly sensitive and specific analytical tool.

引用

页码：8957 / 8979

页数：23

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