The role and therapeutic strategies for tissue-resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

被引：1

作者：

Deng, Guoshu ^{[1
,2
]}

Zhang, Yulin ^{[1
,2
]}

Song, Jiankun ^{[2
]}

Zhang, Ying ^{[2
]}

Zheng, Qi ^{[2
]}

Luo, Yue ^{[2
]}

Fei, Xiaoya ^{[2
]}

Yang, Yang ^{[2
]}

Kuai, Le ^{[1
,2
]}

Li, Bin ^{[2
]}

Luo, Ying ^{[1
,2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Dermatol, Shanghai 200437, Peoples R China

[2] Tongji Univ, Shanghai Skin Dis Hosp, Inst Dermatol, Sch Med, Shanghai 200443, Peoples R China

来源：

IMMUNOLOGY | 2024年 / 173卷 / 03期

关键词：

psoriasis; recurrence; TCM; TEM; TRM; COEXPRESSION; INFLAMMATION; BURDEN; BLOOD;

D O I：

10.1111/imm.13843

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission. It usually lasts a lifetime and necessitates long-term treatment strategies. During periods of activity and remission, one of the main cell types in psoriasis is memory T cells, which include tissue-resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells. They work by releasing inflammatory factors, cytotoxic particles, or altering cell subpopulations, leading to increased inflammation or recurrence. This review summarizes the role of memory T cells in the pathology and treatment of psoriasis, with a view to potential novel therapies and therapeutic targets. The role of tissue-resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells in psoriatic inflammation. image

引用

页码：470 / 480

页数：11

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