Ruthenium(II) Complex-Based Tetradentate Schiff Bases: Synthesis, Spectroscopic, Antioxidant, and Antibacterial Investigations

被引:0
|
作者
Es-Sounni, Bouchra [1 ]
Harboul, Kaoutar [2 ]
Mouhib, Ayoub [3 ]
Alanazi, Ashwag S. [4 ]
Hefnawy, Mohamed [5 ]
Bakhouch, Mohamed [3 ]
Benali, Taoufiq [2 ,6 ]
Hammani, Khalil [2 ]
Mazoir, Noureddine [3 ]
El Yazidi, Mohamed [7 ]
Benharref, Ahmed [8 ]
Fahim, Mohammed [1 ]
机构
[1] Moulay Ismail Univ, Fac Sci, Lab Innovat Mat & Biotechnol Nat Resources, Meknes 50000, Morocco
[2] Sidi Mohamed Ben Abdellah Univ Fez, Polydisciplinary Fac Taza, Lab Nat Resources & Environm, Taza 30050, Morocco
[3] Chouaib Doukkali Univ, Fac Sci, Dept Chem, Bioorgan Chem Team, El Jadida 24000, Morocco
[4] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh 1167, Saudi Arabia
[5] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
[6] Cadi Ayyad Univ, Polydisciplinary Fac Safi, Environm & Hlth Team, Safi 46000, Morocco
[7] Univ Sidi Mohamed Ben Abdellah, Fac Sci Dhar El Mahraz, Engn Lab Organomet & Mol Mat & Environm, Fes 30000, Morocco
[8] Cadi Ayyad Univ, Fac Sci Semlalia, Lab Nat Subst Chem, Marrakech 40000, Morocco
关键词
salen Schiff bases; Ru(II) complexes; spectroscopy; antioxidant; antibacterial; CATALYSTS;
D O I
10.3390/ijms25147879
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this work, we describe the synthesis of novel Ruthenium (II) complex-based salen Schiff bases. The obtained Ruthenium (II) complexes are characterized using usual spectroscopic and spectrometric techniques, viz., IR, UV-Vis, NMR (1H and 13C), powder X-ray diffraction, and HRMS. Further techniques, such as DTA-TGA and elemental analysis, are used to well establish the structure of the obtained complexes. Octahedral geometries are tentatively proposed for the new Ru(II) complexes. The measured molar conductance for the Ruthenium (II) complexes shows their electrolytic nature (4.24-4.44 S/m). The new Ru(II) complexes are evaluated for their antioxidant and antibacterial activities. The DPPH radical scavenging, FRAP, and total antioxidant capacity (TAC) assays show that the obtained complexes are more potent than the used positive control. They also exhibit promising antibacterial responses against pathogen bacteria: [RuH2L3Cl2] exhibits an important inhibition against Bacillus subtilis DSM 6633, with an inhibition zone of 21 +/- 1.41 mm with an MIC value of 0.39 mg/mL, and Proteus mirabilis INH, with 16.50 +/- 0.70 mm and an MIC value of 0.78 mg/mL, while [RuH2L2Cl2] exerts interesting antibacterial effects versus Bacillus subtilis DSM 6633 (21 +/- 1.41 mm) and Proteus mirabilis INH (25.5 +/- 0.70 mm) with equal MIC values of 0.97 mg/mL.
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页数:13
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