Reactive Oxygen Species Mechanisms that Regulate Protein-Protein Interactions in Cancer

被引：5

作者：

Iliadis, Stavros ^{[1
]}

Papanikolaou, Nikolaos A. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Dept Med, Lab Biol Chem,Sect Biol Sci & Prevent Med, Thessaloniki 54124, Macedonia, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

ROS; PPI; cancer; degradation; phosphorylation; kinases; phosphatase; GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; MEDIATED APOPTOSIS; REDOX REGULATION; SIGNALING PATHWAY; OXIDATIVE STRESS; CELL-GROWTH; ACTIVATION; TRANSCRIPTION; PHOSPHATASES;

D O I：

10.3390/ijms25179255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) are produced during cellular metabolism and in response to environmental stress. While low levels of ROS play essential physiological roles, excess ROS can damage cellular components, leading to cell death or transformation. ROS can also regulate protein interactions in cancer cells, thereby affecting processes such as cell growth, migration, and angiogenesis. Dysregulated interactions occur via various mechanisms, including amino acid modifications, conformational changes, and alterations in complex stability. Understanding ROS-mediated changes in protein interactions is crucial for targeted cancer therapies. In this review, we examine the role that ROS mechanisms in regulating pathways through protein-protein interactions.

引用

页数：17

共 113 条

[21] Oxidant Sensing by Reversible Disulfide Bond Formation [J].

Cremers, Claudia M. ;

Jakob, Ursula .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (37) :26489-26496

[22] Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway [J].

Cunnick, JM ;

Dorsey, JF ;

Standley, T ;

Turkson, J ;

Kraker, AJ ;

Fry, DW ;

Jove, R ;

Wu, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) :14468-14475

[23] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity [J].

Daitoku, H ;

Hatta, M ;

Matsuzaki, H ;

Aratani, S ;

Ohshima, T ;

Miyagishi, M ;

Nakajima, T ;

Fukamizu, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :10042-10047

[24] Phospho-regulation of β-catenin adhesion and signaling functions [J].

Daugherty, Rebecca Leadem ;

Gottardi, Cara J. .

PHYSIOLOGY, 2007, 22 (05) :303-309

[25] Transcriptional regulation by hypoxia inducible factors [J].

Dengler, Veronica L. ;

Galbraith, Matthew D. ;

Espinosa, Joaquin M. .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 49 (01) :1-15

[26] Role of 4-hydroxynonenal and its metabolites in signaling [J].

Dwivedi, Seema ;

Sharma, Abha ;

Patrick, Brad ;

Sharma, Rajendra ;

Awasthi, Yogesh C. .

REDOX REPORT, 2007, 12 (1-2) :4-10

[27] ROS induced lipid peroxidation and their role in ferroptosis [J].

Endale, Hiwot Tezera ;

Tesfaye, Winta ;

Mengstie, Tiget Ayelgn .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11

[28] Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function [J].

Fialkow, Lea ;

Wang, Yingchun ;

Downey, Gregory P. .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (02) :153-164

[29] Reactive Oxygen Species in Metabolic and Inflammatory Signaling [J].

Forrester, Steven J. ;

Kikuchi, Daniel S. ;

Hernandes, Marina S. ;

Xu, Qian ;

Griendling, Kathy K. .

CIRCULATION RESEARCH, 2018, 122 (06) :877-+

[30] The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-β-catenin signalling through dishevelled [J].

Funato, Y ;

Michiue, T ;

Asashima, M ;

Miki, H .

NATURE CELL BIOLOGY, 2006, 8 (05) :501-U135

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