Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review

被引:0
作者
Drossel, Gunner [1 ,2 ]
Heilbronner, Sarah R. [3 ]
Zimmermann, Jan [4 ,5 ]
Zilverstand, Anna [2 ,6 ]
机构
[1] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN USA
[2] Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA
[3] Baylor Coll Med, Dept Neurosurg, Houston, TX USA
[4] Univ Minnesota, Dept Neurosci, Minneapolis, MN USA
[5] Univ Minnesota, Ctr Neuroengn, Minneapolis, MN USA
[6] Univ Minnesota, Med Discovery Team Addict, Minneapolis, MN USA
关键词
Functional neuroimaging; FMRI; PET; Drug addiction; Alcohol; Opioid; Cocaine; Nicotine; NEURONAL-ACTIVITY; SEX-DIFFERENCES; BRAIN; COCAINE; ADDICTION; RAT; ALCOHOL; REWARD; MRI; NEUROCIRCUITRY;
D O I
10.1016/j.neubiorev.2024.105823
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
A systematic review of functional neuroimaging studies on drug (self-) administration in rodents is lacking. Here, we summarized effects of acute or chronic drug administration of various classes of drugs on brain function and determined consistency with human literature. We performed a systematic literature search and identified 125 studies on in vivo rodent resting-state functional magnetic resonance imaging (n = 84) or positron emission tomography (n = 41) spanning depressants (n = 27), opioids (n = 23), stimulants (n = 72), and cannabis (n = 3). Results primarily showed alterations in the striatum, consistent with the human literature. The anterior cingulate cortex and (nonspecific) prefrontal cortex were also frequently implicated. Upregulation was most often found after shorter administration and downregulation after long chronic administration, particularly in the striatum. Importantly, results were consistent across study design, administration models, imaging method, and animal states. Results provide evidence of altered resting-state brain function in rodents upon drug administration, implicating the brain's reward network analogous to human studies. However, alterations were more dynamic than previously known, with dynamic adaptation depending on the length of drug administration.
引用
收藏
页数:32
相关论文
共 92 条
  • [1] Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs
    Andersson, C
    Hamer, RM
    Lawler, CP
    Mailman, RB
    Lieberman, JA
    [J]. NEUROPSYCHOPHARMACOLOGY, 2002, 27 (02) : 143 - 151
  • [2] Primate homologs of mouse cortico-striatal circuits
    Balsters, Joshua Henk
    Zerbi, Valerio
    Sallee, Jerome
    Wenderoth, Nicole
    Mars, Rogier B.
    [J]. ELIFE, 2020, 9
  • [3] Neuroimaging Studies of Acute Effects of THC and CBD in Humans and Animals: a Systematic Review
    Batalla, A.
    Crippa, J. A.
    Busatto, G. F.
    Guimaraes, F. S.
    Zuardi, A. W.
    Valverde, O.
    Atakan, Z.
    McGuire, P. K.
    Bhattacharyya, S.
    Martin-Santos, R.
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (13) : 2168 - 2185
  • [4] Brain networks of rats under anesthesia using resting-state fMRI: comparison with dead rats, random noise and generative models of networks
    Becq, G. J-P C.
    Barbier, E. L.
    Achard, S.
    [J]. JOURNAL OF NEURAL ENGINEERING, 2020, 17 (04)
  • [5] The debate over dopamine's role in reward: the case for incentive salience
    Berridge, Kent C.
    [J]. PSYCHOPHARMACOLOGY, 2007, 191 (03) : 391 - 431
  • [6] Bukhari Q, 2017, FRONT NEURAL CIRCUIT, V11, DOI [10.3389/fncir.2017.0000.5, 10.3389/fncir.2017.00005]
  • [7] Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse
    Carnicella, Sebastien
    Ron, Dorit
    Barak, Segev
    [J]. ALCOHOL, 2014, 48 (03) : 243 - 252
  • [8] Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model
    Charlton, Annai J.
    May, Carlos
    Luikinga, Sophia J.
    Burrows, Emma L.
    Kim, Jee Hyun
    Lawrence, Andrew J.
    Perry, Christina J.
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [9] Heroin self-administration as a function of time of day in rats
    Coffey, A. A.
    Fang, J.
    Grigson, Patricia S.
    [J]. PSYCHOPHARMACOLOGY, 2018, 235 (10) : 3005 - 3015
  • [10] Changes in brain structure and function following chronic exposure to inhaled vaporised cannabis during periadolescence in female and male mice: A multimodal MRI study
    Coleman, James R.
    Madularu, Dan
    Ortiz, Richard J.
    Athanassiou, Maria
    Knudsen, Alexa
    Alkislar, Ilayda
    Cai, Xuezhu
    Kulkarni, Praveen P.
    Cushing, Bruce S.
    Ferris, Craig F.
    [J]. ADDICTION BIOLOGY, 2022, 27 (03)