A systematic review of functional neuroimaging studies on drug (self-) administration in rodents is lacking. Here, we summarized effects of acute or chronic drug administration of various classes of drugs on brain function and determined consistency with human literature. We performed a systematic literature search and identified 125 studies on in vivo rodent resting-state functional magnetic resonance imaging (n = 84) or positron emission tomography (n = 41) spanning depressants (n = 27), opioids (n = 23), stimulants (n = 72), and cannabis (n = 3). Results primarily showed alterations in the striatum, consistent with the human literature. The anterior cingulate cortex and (nonspecific) prefrontal cortex were also frequently implicated. Upregulation was most often found after shorter administration and downregulation after long chronic administration, particularly in the striatum. Importantly, results were consistent across study design, administration models, imaging method, and animal states. Results provide evidence of altered resting-state brain function in rodents upon drug administration, implicating the brain's reward network analogous to human studies. However, alterations were more dynamic than previously known, with dynamic adaptation depending on the length of drug administration.
机构:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Sao Paulo, Brazil
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Crippa, J. A.
Busatto, G. F.
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Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Dept & Inst Psychiat, Fac Med, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Busatto, G. F.
Guimaraes, F. S.
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h-index: 0
机构:
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Guimaraes, F. S.
Zuardi, A. W.
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h-index: 0
机构:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Sao Paulo, Brazil
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
机构:
Univ Calif San Francisco, Dept Neurol, Gallo Res Ctr, San Francisco, CA USAGrenoble Inst Neurosci Dynam & Physiopathol Gangl, INSERM, U836, Grenoble, France
Ron, Dorit
Barak, Segev
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机构:
Tel Aviv Univ, Sch Psychol Sci, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, IsraelGrenoble Inst Neurosci Dynam & Physiopathol Gangl, INSERM, U836, Grenoble, France
机构:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Sao Paulo, Brazil
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Crippa, J. A.
Busatto, G. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Dept & Inst Psychiat, Fac Med, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Busatto, G. F.
Guimaraes, F. S.
论文数: 0引用数: 0
h-index: 0
机构:
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
Guimaraes, F. S.
Zuardi, A. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Sao Paulo, Brazil
INCT Translat Med CNPq, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilHosp Clin Barcelona, IDIBAPS, CIBERSAM, Inst Neurosci, Barcelona, Spain
机构:
Univ Calif San Francisco, Dept Neurol, Gallo Res Ctr, San Francisco, CA USAGrenoble Inst Neurosci Dynam & Physiopathol Gangl, INSERM, U836, Grenoble, France
Ron, Dorit
Barak, Segev
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sch Psychol Sci, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, IsraelGrenoble Inst Neurosci Dynam & Physiopathol Gangl, INSERM, U836, Grenoble, France