Annexin A2: A Double-Edged Sword in Pathogen Infection

被引：0
|
作者：
Wang, Tianyu [1 ,2 ]
Zhao, Dengshuai [1 ]
Zhang, Yuanhang [1 ]
Yu, Dixi [1 ]
Liu, Guoping [2 ]
Zhang, Keshan [1 ]
机构：
[1] Foshan Univ, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan 528225, Peoples R China
[2] Yangtze Univ, Coll Anim Sci & Technol, Jingzhou 434023, Peoples R China
来源：
PATHOGENS | 2024年 / 13卷 / 07期
关键词：
annexin A2; inflammation; virus; bacteria; SWINE-FEVER VIRUS; NF-KAPPA-B; RESPIRATORY SYNDROME; BREAST-CANCER; CRYPTOCOCCUS-NEOFORMANS; MESENCHYMAL TRANSITION; VIRULENCE DETERMINANT; PSEUDORABIES VIRUS; E2; GLYCOPROTEIN; VIRAL NSP9;
D O I：
10.3390/pathogens13070564
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Annexin A2 (ANXA2) is a multifunctional calcium- and phospholipid-binding protein that plays an important role in various cells. During pathogen infections, ANXA2 modulates the nuclear factor kappa-B (NF-kappa B) and cell apoptosis signaling pathways and guides the chemotaxis of inflammatory cells toward inflammation sites, thereby protecting the host organism through the modulation of the inflammatory response. In addition, ANXA2 can regulate immune responses, and in certain pathogen infections, it can interact with pathogen proteins to facilitate their invasion and proliferation. This review provides an overview of the research progress on how ANXA2 regulates pathogen infections.
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页数：15
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