The effects of ciclosporin and methotrexate on kidney function in the treatment of severe atopic dermatitis in children: results from the TREAT trial

被引：0

作者：

Bruce, Gordon ^{[1
]}

Rosala-Hallas, Anna ^{[2
]}

Jones, Ashley P. ^{[2
]}

Turner, Charles ^{[3
]}

Dalton, Neil ^{[3
]}

Hilger, Eva ^{[4
,5
]}

Baron, Susannah ^{[4
,5
]}

Beattie, Paula ^{[6
]}

Browne, Fiona ^{[7
]}

Brown, Sara J. ^{[8
]}

Gach, Joanna E. ^{[9
]}

Hearn, Ross ^{[10
]}

Esdaile, Ben ^{[11
]}

Cork, Mike J. ^{[12
,13
]}

Howard, Emma ^{[4
,5
]}

Greenblatt, Danielle ^{[4
,5
]}

August, Suzannah ^{[14
]}

Lovgren, Marie-Louise ^{[15
]}

Ashoor, Farhiya ^{[2
]}

McPherson, Tess ^{[16
]}

O'Kane, Donal ^{[17
]}

Ravenscroft, Jane ^{[18
]}

Shaw, Lindsay ^{[19
]}

Spowart, Catherine ^{[2
]}

Thomas, Bjorn R. ^{[20
,21
]}

Sach, Tracey ^{[22
]}

Wan, Mandy ^{[3
,23
]}

Irvine, Alan D. ^{[24
,25
,26
]}

Sinha, Manish D. ^{[1
]}

Flohr, Carsten ^{[4
,5
]}

机构：

[1] Kings Coll London, Evelina London Childrens Hosp, Dept Paediat Nephrol, London, England

[2] Univ Liverpool, Liverpool Clin Trials Ctr, Liverpool, England

[3] Evelina Childrens Hosp, London, England

[4] Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, Dept Paediat Dermatol, London, England

[5] Kings Coll London, London, England

[6] Royal Hosp Children NHS Trust, Glasgow, Scotland

[7] Childrens Hlth Ireland Crumlin, Paediat Dermatol, Dublin, Ireland

[8] Univ Edinburgh, Ctr Genom & Expt Med, Edinburgh, Scotland

[9] Univ Hosp Coventry & Warwickshire, Coventry, England

[10] Ninewells Hosp & Med Sch, Dundee, Scotland

[11] Whittington Hlth NHS Trust, Whittington Hosp, London, England

[12] Univ Sheffield, Sheffield Childrens NHS Fdn Trust, Sheffield, England

[13] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield Dermatol Res, Sheffield, England

[14] Univ Hosp Dorset NHS Fdn Trust, Poole, Dorset, England

[15] Birmingham Childrens Hosp, Birmingham Womens & Childrens NHS Fdn Trust, Birmingham, England

[16] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[17] Belfast Hlth & Social Care Trust, Dept Dermatol, Belfast, North Ireland

[18] Nottingham Univ Hosp NHS Trust, Nottingham, England

[19] Bristol Royal Hosp Children, Bristol, England

[20] Queen Mary Univ London, Royal Free Hosp, London, England

[21] Queen Mary Univ, Blizard Inst, London, England

[22] Univ East Anglia, Norwich Med Sch, Hlth Econ Grp, Norwich, England

[23] Kings Coll London, Inst Pharmaceut Sci, London, England

[24] Trinity Coll Dublin, Clin Med, Dublin, Ireland

[25] Childrens Hlth Ireland Crumlin, Paediat Dermatol, Dublin, Ireland

[26] Natl Childrens Res Ctr, Dublin, Ireland

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/bjd/ljae276

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ciclosporin (CyA) and methotrexate (MTX) are frequently prescribed drugs for the treatment of atopic dermatitis in children and young people. Both can affect renal function and frequent blood monitoring is standard to monitor safety. We show that both CyA and MTX are not associated with decreased renal function and are safe and effective as a treatment for atopic dermatitis in children and young people.

引用

页码：851 / 852

页数：2

共 50 条

[41] Methotrexate and azathioprine in severe atopic dermatitis: a randomized controlled trial and open-label extension study
Roekevisch, E.
Schram, M. E.
Gerbens, L. A. A.
Hamann, S. A. S.
Leeflang, M. M. G.
Brouwer, M. W. D.
Bos, J. D.
Spuls, P. I.
BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (01) : E45 - E45
[42] Immunologic Effects of Omalizumab in Children with Severe Refractory Atopic Dermatitis: A Randomized, Placebo-Controlled Clinical Trial
Iyengar, Shuba Rajashri
Hoyte, Elizabeth G.
Loza, Angelica
Bonaccorso, Salvatore
Chiang, David
Umetsu, Dale T.
Nadeau, Kari Christine
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2013, 162 (01) : 89 - 93
[43] Does montelukast reduce the treatment cost in children with moderately severe atopic dermatitis?
Ehlayel, M.
Bener, A.
ALLERGY, 2008, 63 : 274 - 274
[44] Montelukast in the treatment of children with moderate-to-severe atopic dermatitis: A pilot study
Pei, AYS
Chan, HHL
Leung, TF
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2001, 12 (03) : 154 - 158
[45] Treatment of moderate-to-severe atopic dermatitis with baricitinib: Results from an interim analysis of the TREATgermany registry
Traidl, Stephan
Heinrich, Luise
Siegels, Doreen
Heratizadeh, Annice
Kind, Barbara
Haufe, Eva
Abraham, Susanne
Schaefer, Thomas
Augustin, Matthias
Harder, Inken
Pinter, Andreas
Schaekel, Knut
Wollenberg, Andreas
Ertner, Konstantin
Ramaker-Brunke, Jutta
Bong, Anne
Quist, Sven
Gorriahn-Maiterth, Hannah
Schenck, Florian
Sticherling, Michael
Effendy, Isaak
Schwarz, Beate
Handrick, Christiane
Asmussen, Andrea
Weidinger, Stephan
Schmitt, Jochen
Werfel, Thomas
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2024, 38 (10) : e887 - e891
[46] Results from 1 year of treatment with lebrikizumab for atopic dermatitis
不详
BRITISH JOURNAL OF DERMATOLOGY, 2023, 188 (06) : E43 - E43
[47] Which Arthralgia Patients at Risk for RA Benefited from Treatment with Methotrexate?; Results from the TREAT EARLIER Trial
Claassen, Stijn
Dumoulin, Quirine
Glas, Kasper
Molenaar, Esmeralda
van Steenbergen, Hanna
van der Helm-van Mil, Annette
ARTHRITIS & RHEUMATOLOGY, 2024, 76 : 5425 - 5425
[48] Methotrexate for treatment of atopic dermatitis in children and adolescents: A retrospective study at Waikato District Health Board
Deo, M.
Rademaker, M.
Yung, A.
Hill, S.
AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2012, 53 : 17 - 17
[49] Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial
Carucci, Laura
Nocerino, Rita
Paparo, Lorella
De Filippis, Francesca
Coppola, Serena
Giglio, Veronica
Cozzolino, Tommaso
Valentino, Vincenzo
Sequino, Giuseppina
Bedogni, Giorgio
Russo, Roberto
Ercolini, Danilo
Canani, Roberto Berni
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2022, 33 (08)
[50] Methotrexate Versus Cyclosporine in Adults with Moderate-to-Severe Atopic Dermatitis: A Phase III Randomized Noninferiority Trial
Goujon, Catherine
Viguier, Manuelle
Staumont-Salle, Delphine
Bernier, Claire
Guillet, Gerard
Lahfa, Morad
Le Bouedec, Marie-Christine Ferrier
Cambazard, Frederic
Bottigioli, David
Grande, Sophie
Dahel, Karima
Berard, Frederic
Rabilloud, Muriel
Mercier, Catherine
Nicolas, Jean-Francois
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (02): : 562 - +

← 1 2 3 4 5 →