The effects of ciclosporin and methotrexate on kidney function in the treatment of severe atopic dermatitis in children: results from the TREAT trial

被引：0

作者：

Bruce, Gordon ^{[1
]}

Rosala-Hallas, Anna ^{[2
]}

Jones, Ashley P. ^{[2
]}

Turner, Charles ^{[3
]}

Dalton, Neil ^{[3
]}

Hilger, Eva ^{[4
,5
]}

Baron, Susannah ^{[4
,5
]}

Beattie, Paula ^{[6
]}

Browne, Fiona ^{[7
]}

Brown, Sara J. ^{[8
]}

Gach, Joanna E. ^{[9
]}

Hearn, Ross ^{[10
]}

Esdaile, Ben ^{[11
]}

Cork, Mike J. ^{[12
,13
]}

Howard, Emma ^{[4
,5
]}

Greenblatt, Danielle ^{[4
,5
]}

August, Suzannah ^{[14
]}

Lovgren, Marie-Louise ^{[15
]}

Ashoor, Farhiya ^{[2
]}

McPherson, Tess ^{[16
]}

O'Kane, Donal ^{[17
]}

Ravenscroft, Jane ^{[18
]}

Shaw, Lindsay ^{[19
]}

Spowart, Catherine ^{[2
]}

Thomas, Bjorn R. ^{[20
,21
]}

Sach, Tracey ^{[22
]}

Wan, Mandy ^{[3
,23
]}

Irvine, Alan D. ^{[24
,25
,26
]}

Sinha, Manish D. ^{[1
]}

Flohr, Carsten ^{[4
,5
]}

机构：

[1] Kings Coll London, Evelina London Childrens Hosp, Dept Paediat Nephrol, London, England

[2] Univ Liverpool, Liverpool Clin Trials Ctr, Liverpool, England

[3] Evelina Childrens Hosp, London, England

[4] Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, Dept Paediat Dermatol, London, England

[5] Kings Coll London, London, England

[6] Royal Hosp Children NHS Trust, Glasgow, Scotland

[7] Childrens Hlth Ireland Crumlin, Paediat Dermatol, Dublin, Ireland

[8] Univ Edinburgh, Ctr Genom & Expt Med, Edinburgh, Scotland

[9] Univ Hosp Coventry & Warwickshire, Coventry, England

[10] Ninewells Hosp & Med Sch, Dundee, Scotland

[11] Whittington Hlth NHS Trust, Whittington Hosp, London, England

[12] Univ Sheffield, Sheffield Childrens NHS Fdn Trust, Sheffield, England

[13] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield Dermatol Res, Sheffield, England

[14] Univ Hosp Dorset NHS Fdn Trust, Poole, Dorset, England

[15] Birmingham Childrens Hosp, Birmingham Womens & Childrens NHS Fdn Trust, Birmingham, England

[16] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[17] Belfast Hlth & Social Care Trust, Dept Dermatol, Belfast, North Ireland

[18] Nottingham Univ Hosp NHS Trust, Nottingham, England

[19] Bristol Royal Hosp Children, Bristol, England

[20] Queen Mary Univ London, Royal Free Hosp, London, England

[21] Queen Mary Univ, Blizard Inst, London, England

[22] Univ East Anglia, Norwich Med Sch, Hlth Econ Grp, Norwich, England

[23] Kings Coll London, Inst Pharmaceut Sci, London, England

[24] Trinity Coll Dublin, Clin Med, Dublin, Ireland

[25] Childrens Hlth Ireland Crumlin, Paediat Dermatol, Dublin, Ireland

[26] Natl Childrens Res Ctr, Dublin, Ireland

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/bjd/ljae276

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ciclosporin (CyA) and methotrexate (MTX) are frequently prescribed drugs for the treatment of atopic dermatitis in children and young people. Both can affect renal function and frequent blood monitoring is standard to monitor safety. We show that both CyA and MTX are not associated with decreased renal function and are safe and effective as a treatment for atopic dermatitis in children and young people.

引用

页码：851 / 852

页数：2

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