C-C Motif Chemokine Ligand 2 and Chemokine Receptor 2 in Cardiovascular and Neural Aging and Aging-Related Diseases

被引：0
作者：
Guo, David [1 ]
Zhu, Wuqiang [2 ]
Qiu, Hongyu [1 ,3 ]
机构：
[1] Univ Arizona, Coll Med Phoenix, Cardiovasc Translat Res Ctr, Dept Internal Med, Phoenix, AZ 85004 USA
[2] Mayo Clin Arizona, Ctr Regenerat Biotherapeut, Dept Cardiovasc Med Physiol & Biomed Engn, Scottsdale, AZ 85259 USA
[3] Univ Arizona, Clin Translat Sci CTS & Inst Bio5, Tucson, AZ 85721 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 16期
关键词：
aging; CCL2/CCR2; inflammation; cardiovascular diseases; neural; cancer; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; AMYLOID-BETA; CCR2; CCL2; DEFICIENCY; ACTIVATION; EXPRESSION; MONOCYTES; MECHANISMS; MACROPHAGE;
D O I：
10.3390/ijms25168794
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is a prominent risk factor for numerous chronic diseases. Understanding the shared mechanisms of aging can aid in pinpointing therapeutic targets for age-related disorders. Chronic inflammation has emerged as a pivotal mediator of aging and a determinant in various age-related chronic conditions. Recent findings indicate that C-C motif chemokine ligand 2 and receptor 2 (CCL2-CCR2) signaling, an important physiological modulator in innate immune response and inflammatory defense, plays a crucial role in aging-related disorders and is increasingly recognized as a promising therapeutic target, highlighting its significance. This review summarizes recent advances in the investigation of CCL2-CCR2 signaling in cardiovascular and neural aging, as well as in various aging-related disorders. It also explores the underlying mechanisms and therapeutic potentials in these contexts. These insights aim to deepen our understanding of aging pathophysiology and the development of aging-related diseases.
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页数：16
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