Good parent-child relationship protects against alcohol use in maltreated adolescent females carrying the MAOA-uVNTR susceptibility allele

被引：0

作者：

Bendre, Megha ^{[1
,2
]}

Checknita, David ^{[1
,2
,3
]}

Todkar, Aniruddha ^{[1
,2
]}

Aslund, Cecilia ^{[2
,4
]}

Hodgins, Sheilagh ^{[5
,6
]}

Nilsson, Kent W. ^{[1
,2
,7
]}

机构：

[1] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

[2] Uppsala Univ, Ctr Clin Res, Vasteras, Sweden

[3] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[4] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden

[5] Univ Montreal, Ctr Rech Inst Natl Psychiat Legale Philippe Pinel, Montreal, PQ, Canada

[6] Univ Montreal, Dept Psychiat, Montreal, PQ, Canada

[7] Malardalen Univ, Sch Hlth Care & Social Welf, Div Publ Hlth Sci, Vasteras, Sweden

来源：

FRONTIERS IN PSYCHIATRY | 2024年 / 15卷

基金：

瑞典研究理事会;

关键词：

monoamine oxidase A (MAOA) gene; maltreatment; parent-child relationship; alcohol; adolescents; gene-environment interactions (GxE); differential susceptibility; candidate gene; OXIDASE-A GENE; MONOAMINE-OXIDASE; ENVIRONMENT INTERACTION; MENTAL-HEALTH; DRUG-USE; FUNCTIONAL POLYMORPHISM; SEXUAL-ABUSE; LIFE EVENTS; GENOTYPE; ASSOCIATION;

D O I：

10.3389/fpsyt.2024.1375363

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Introduction: Risk-allele carriers of a Monoamine oxidase A (MAOA) gene, short-allele (MAOA-S) in males and long-allele (MAOA-L) in females, in the presence of a negative environment, are associated with alcohol misuse. Whether MAOA-S/L alleles also present susceptibility to a positive environment to mitigate the risk of alcohol misuse is unknown. Thus, we assessed the association of the three-way interaction of MAOA, maltreatment, and positive parent-child relationship with alcohol consumption among adolescents. Methods: This prospective study included 1416 adolescents (females: 59.88%) aged 16- 19 years from Sweden, enrolled in the "Survey of Adolescent Life in Vastmanland" in 2012. Adolescents self-reported alcohol consumption, maltreatment by a family (FM) or non-family member (NFM), parent-child relationship, and left saliva for MAOA genotyping. Results and discussion: We observed sex-dependent results. Females carrying MAOA-L with FM or NFM and a good parent-child relationship reported lower alcohol consumption than those with an average or poor parent-child relationship. In males, the interactions were not significant. Results suggest MAOA-L in females, conventionally regarded as a "risk", is a "plasticity" allele as it is differentially susceptible to negative and positive environments. Results highlight the importance of a good parent-child relationship in mitigating the risk of alcohol misuse in maltreated individuals carrying genetic risk. However, the interactions were not significant after adjusting to several environmental and behavioural covariates, especially parent's alcohol use, negative parent-child relationship, and nicotine use (smoking and/or snus), suggesting predictor and outcome intersection. Future studies and frameworks for preventive strategies should consider these covariates together with alcohol consumption. More studies with larger sample sizes are needed to replicate the findings.

引用

页数：17