Developments in Alloplastic Bone Grafts and Barrier Membrane Biomaterials for Periodontal Guided Tissue and Bone Regeneration Therapy

被引:7
作者
Ashfaq, Rabia [1 ]
Kovacs, Anita [1 ]
Berko, Szilvia [1 ]
Budai-Szucs, Maria [1 ]
机构
[1] Univ Szeged, Fac Pharm, Inst Pharmaceut Technol & Regulatory Affairs, Eotvos U 6, H-6720 Szeged, Hungary
关键词
autografts; xenografts; allografts; synthetic biomaterials; guided bone regeneration; alloplastic; periodontitis; membrane barriers; guided tissue regeneration; BIPHASIC CALCIUM-PHOSPHATE; GROWTH-FACTORS; TRICALCIUM PHOSPHATE; IN-VITRO; SUBSTITUTES; ALLOGRAFTS; IMPLANTS; DEFECTS; HYDROXYAPATITE; SCAFFOLDS;
D O I
10.3390/ijms25147746
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Periodontitis is a serious form of oral gum inflammation with recession of gingival soft tissue, destruction of the periodontal ligament, and absorption of alveolar bone. Management of periodontal tissue and bone destruction, along with the restoration of functionality and structural integrity, is not possible with conventional clinical therapy alone. Guided bone and tissue regeneration therapy employs an occlusive biodegradable barrier membrane and graft biomaterials to guide the formation of alveolar bone and tissues for periodontal restoration and regeneration. Amongst several grafting approaches, alloplastic grafts/biomaterials, either derived from natural sources, synthesization, or a combination of both, offer a wide variety of resources tailored to multiple needs. Examining several pertinent scientific databases (Web of Science, Scopus, PubMed, MEDLINE, and Cochrane Library) provided the foundation to cover the literature on synthetic graft materials and membranes, devoted to achieving periodontal tissue and bone regeneration. This discussion proceeds by highlighting potential grafting and barrier biomaterials, their characteristics, efficiency, regenerative ability, therapy outcomes, and advancements in periodontal guided regeneration therapy. Marketed and standardized quality products made of grafts and membrane biomaterials have been documented in this work. Conclusively, this paper illustrates the challenges, risk factors, and combination of biomaterials and drug delivery systems with which to reconstruct the hierarchical periodontium.
引用
收藏
页数:40
相关论文
共 181 条
  • [1] New biodegradable nanoparticles-in-nanofibers based membranes for guided periodontal tissue and bone regeneration with enhanced antibacterial activity
    Abdelaziz, Dina
    Hefnawy, Amr
    Al-Wakeel, Essam
    El-Fallal, Abeer
    El-Sherbiny, Ibrahim M.
    [J]. JOURNAL OF ADVANCED RESEARCH, 2021, 28 : 51 - 62
  • [2] Clinicoradiological outcomes following single-stage treatment using external fixator, copious bone grafting and high dose antibiotics for infected postosteomyelitic nonunion of femoral shaft
    Agarwal, Anil
    Yogendra Raj, Rahul
    Shanker, Mukesh
    [J]. JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, 2021, 30 (01): : 85 - 92
  • [3] Agrawal S., 2020, Racing for the Surface, P355, DOI [10.1007/978-3-030-34471-915, DOI 10.1007/978-3-030-34471-915]
  • [4] Growth factor delivery: Defining the next generation platforms for tissue engineering
    Aguilar, Lilith M. Caballero
    Silva, Saimon M.
    Moulton, Simon E.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2019, 306 : 40 - 58
  • [5] Interaction of stem cells with nano hydroxyapatite-fucoidan bionanocomposites for bone tissue regeneration
    Ahn, Tae Young
    Kang, Jeong Han
    Kang, Dong Jun
    Venkatesan, Jayachandran
    Chang, Hee Kyung
    Bhatnagar, Ira
    Chang, Kwan-Young
    Hwang, Jae-Ho
    Salameh, Ziad
    Kim, Se-Kwon
    Kim, Hui Taek
    Kim, Dong Gyu
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 93 : 1488 - 1491
  • [6] The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to AQP5-positive and αSMA-positive cells in vitro and in vivo
    Akashi, Yoshihiko
    Nemoto, Atsushi
    Nakajima, Kei
    Kokubun, Katsutoshi
    Murakami, Satoshi
    Inoue, Takashi
    Matsuzaka, Kenichi
    [J]. CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 2021, 7 (03): : 344 - 353
  • [7] Albee FH, 1920, ANN SURG, V71, P32
  • [8] Structural and chemical features of xenograft bone substitutes: A systematic review of in vitro studies
    Amid, Reza
    Kheiri, Aida
    Kheiri, Lida
    Kadkhodazadeh, Mahdi
    Ekhlasmandkermani, Mehdi
    [J]. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2021, 68 (06) : 1432 - 1452
  • [9] Physicochemical characterization of five different bone graft substitutes used in periodontal regeneration: an in vitro study
    Anil, Aiswarya
    Sadasivan, Arun
    Koshi, Elizabeth
    [J]. JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY, 2020, 10 (05) : 634 - 642
  • [10] [Anonymous], Nanoscale Hydroxyapatite Particles for Bone Tissue Engineering-ScienceDirect